Entity Details

Primary name TLE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04724
EntryNameTLE1_HUMAN
FullNameTransducin-like enhancer protein 1
TaxID9606
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesTLE1

GO terms

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GOName
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0008134 transcription factor binding
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly
GO:1990907 beta-catenin-TCF complex
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR005617 Groucho/TLE, N-terminal Q-rich domainDomainDomain
IPR009146 Groucho/transducin-like enhancerFamilyFamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
TLE1_HUMANHIPK2_HUMANMINT15896780 details
TLE1_HUMANFUBP1_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANRFA2_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANSAT1_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANZF64B_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANARL4D_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANBTBD2_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANIF2B_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANERH_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANCH10_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANMPH6_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANPA1B3_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANPCDA4_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANPSD11_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANSPB9_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANKITH_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TLE1_HUMANARL3_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANCCL18_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANCDN2C_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANFXYD6_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANGSTM4_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANDQA1_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANCRCT1_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANDPOE2_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANPEX2_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANRNF10_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANRUXG_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANCELF3_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANPROF1_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANDPOLB_HUMANBioGRID, HPRD, IntAct16169070 details
TLE1_HUMANDAZP2_HUMANBioGRID, HPRD, IntAct, MINT16169070 20211142 21900206 details
TLE1_HUMANRUNX1_HUMANBioGRID, HPRD, IntAct9751710 details
TLE1_HUMANRUNX3_HUMANBioGRID, HPRD, IntAct9751710 details
TLE1_HUMANLEF1_HUMANBioGRID, HPRD, IntAct15768032 9751710 details
TLE1_HUMANAPH1A_HUMANBioGRID, IntAct21988832 details
TLE1_HUMANANXA7_HUMANBioGRID, MINT21900206 details
TLE1_HUMANB2CL1_HUMANBioGRID, MINT21900206 details
TLE1_HUMANBID_HUMANBioGRID, MINT21900206 details
TLE1_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
TLE1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
TLE1_HUMANGA45A_HUMANBioGRID, MINT21900206 details
TLE1_HUMANGRB7_HUMANBioGRID, MINT21900206 details
TLE1_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
TLE1_HUMANCPSF5_HUMANBioGRID, MINT21900206 details
TLE1_HUMANRAP1B_HUMANBioGRID, MINT21900206 details
TLE1_HUMANRCC1_HUMANBioGRID, MINT21900206 details
TLE1_HUMANSMN_HUMANBioGRID, MINT21900206 details
TLE1_HUMANK0408_HUMANBioGRID, MINT21900206 details
TLE1_HUMANT22D1_HUMANBioGRID, MINT21900206 details
TLE1_HUMANSIR1_HUMANBioGRID, UniProt17680780 details
TLE1_HUMANHDAC1_HUMANBioGRID, IntAct19101520 22439931 details
TLE1_HUMANTLE1_HUMANBioGRID, HPRD, MINT22354967 24596249 9874198 details
TLE1_HUMANITF2_HUMANBioGRID, MINT24596249 details
TLE1_HUMANH4_HUMANMINT24596249 details
TLE1_HUMANNOD2_HUMANBioGRID, IntAct21699783 details
TLE1_HUMANTLE2_HUMANBioGRID, HPRD, MINT24981860 9874198 details
TLE1_HUMANGRN_HUMANIntAct32814053 details
TLE1_HUMANHEXB_HUMANIntAct32814053 details
TLE1_HUMANPRKN_HUMANIntAct32814053 details
TLE1_HUMANATX10_HUMANIntAct32814053 details
TLE1_HUMANRNF11_HUMANIntAct32814053 details
TLE1_HUMANVENTX_HUMANBioGRID, IntAct20211142 28514442 details
TLE1_HUMANTLX3_HUMANBioGRID, IntAct19250647 20211142 details
TLE1_HUMANHES6_HUMANBioGRID, HPRD, IntAct11551980 20211142 details
TLE1_HUMANBARH1_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANPAX9_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANMSX2_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANTLX2_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANFOXA3_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANFOXA2_HUMANBioGRID, HPRD, IntAct10748198 20211142 details
TLE1_HUMANFOXA1_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANNKX25_HUMANBioGRID, IntAct20211142 details
TLE1_HUMANFOXG1_HUMANBioGRID, HPRD, MINT11238932 16314515 18611861 22354967 24356439 details
TLE1_HUMANIL6RB_HUMANBioGRID, HPRD12030375 details
TLE1_HUMANATN1_HUMANBioGRID, HPRD16169070 details
TLE1_HUMANUTY_HUMANBioGRID, HPRD9854018 details
TLE1_HUMANKDM6A_HUMANBioGRID, HPRD9854018 details
TLE1_HUMANSIX3_HUMANBioGRID, HPRD12441302 details
TLE1_HUMANSIX6_HUMANBioGRID, HPRD12441302 details
TLE1_HUMANHMGB1_HUMANBioGRID, HPRD11748221 details
TLE1_HUMANPRDM1_HUMANBioGRID, HPRD9887105 details
TLE1_HUMANCTNB1_HUMANBioGRID9751710 details
TLE1_HUMANHME1_HUMANBioGRID16571670 18611861 details
TLE1_HUMANHESX1_HUMANBioGRID11731482 details
TLE1_HUMANERR3_HUMANBioGRID14651967 details
TLE1_HUMANHHEX_HUMANBioGRID, HPRD15187083 details
TLE1_HUMANTLX1_HUMANBioGRID19250647 details
TLE1_HUMANHES1_HUMANBioGRID, HPRD18611861 19321451 8687460 details
TLE1_HUMANTFE2_HUMANBioGRID18611861 24596249 details
TLE1_HUMANSIX2_HUMANBioGRID, HPRD12441302 28514442 details
TLE1_HUMANSIX1_HUMANHPRD12441302 details
TLE1_HUMANRERE_HUMANIntAct16169070 details
TLE1_HUMANTYB4_HUMANIntAct16169070 details
TLE1_HUMANLEU1_HUMANIntAct16169070 details
TLE1_HUMANTLE5_HUMANBioGRID, IntAct17353931 22354967 details
TLE1_HUMANVHL_HUMANIntAct17353931 details
TLE1_HUMANTF65_HUMANBioGRID10660609 details
TLE1_HUMANPROP1_HUMANBioGRID20181723 details
TLE1_HUMANSSXT_HUMANBioGRID22439931 details
TLE1_HUMANSSX2_HUMANBioGRID22439931 details
TLE1_HUMANTLE4_HUMANBioGRID16314515 24981860 28514442 details
TLE1_HUMANHEY1_HUMANBioGRID19321451 details
TLE1_HUMANSMG7_HUMANBioGRID29395067 details
TLE1_HUMANPRC2B_HUMANBioGRID29395067 details
TLE1_HUMANMO4L2_HUMANHPRD12391155 details
TLE1_HUMANCDK1_HUMANHPRD12397081 details
TLE1_HUMANMSX1_HUMANHPRD16002402 details
TLE1_HUMANHNF1A_HUMANHPRD10209158 details