Entity Details

Primary name RN5A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05823
EntryNameRN5A_HUMAN
FullName2-5A-dependent ribonuclease
TaxID9606
Evidenceevidence at protein level
Length741
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesRNASEL

GO terms

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GOName
GO:0003723 RNA binding
GO:0004521 endoribonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0016363 nuclear matrix
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0043488 regulation of mRNA stability
GO:0045071 negative regulation of viral genome replication
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046872 metal ion binding
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR010513 KEN domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR038357 KEN domain superfamilyFamilyHomologous superfamily
IPR042745 RNase L, RNase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
601518 OMIMProstate cancer, hereditary, 1 (HPC1)A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Disease susceptibility is associated with variants affecting the gene represented in this entry.
176807 OMIMProstate cancer (PC)A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.