Entity Details

Primary name PDE4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07343
EntryNamePDE4B_HUMAN
FullNamecAMP-specific 3',5'-cyclic phosphodiesterase 4B
TaxID9606
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesPDE4B

GO terms

Show/Hide Table
GOName
GO:0000930 gamma-tubulin complex
GO:0001780 neutrophil homeostasis
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005891 voltage-gated calcium channel complex
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0008021 synaptic vesicle
GO:0014069 postsynaptic density
GO:0030018 Z disc
GO:0030552 cAMP binding
GO:0030593 neutrophil chemotaxis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0035690 cellular response to drug
GO:0043015 gamma-tubulin binding
GO:0043197 dendritic spine
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0060076 excitatory synapse
GO:0071222 cellular response to lipopolysaccharide
GO:0071872 cellular response to epinephrine stimulus
GO:0086004 regulation of cardiac muscle cell contraction
GO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901898 negative regulation of relaxation of cardiac muscle

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily
IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)DomainDomain
IPR043371 cAMP-specific 3',5'-cyclic phosphodiesterase 4FamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB00824 EnprofyllineDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB01113 PapaverineDrugbanksmall molecule
DB01412 TheobromineDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB01647 DaxalipramDrugbanksmall molecule
DB01656 RoflumilastDrugbanksmall molecule
DB01791 PiclamilastDrugbanksmall molecule
DB01954 RolipramDrugbanksmall molecule
DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB02660 FilaminastDrugbanksmall molecule
DB03349 8-Bromo-Adenosine-5'-MonophosphateDrugbanksmall molecule
DB03606 (S)-RolipramDrugbanksmall molecule
DB03807 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB03849 CilomilastDrugbanksmall molecule
DB04149 (R)-RolipramDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05266 IbudilastDrugbanksmall molecule
DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideDrugbanksmall molecule
DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule