Entity Details

Primary name HYAL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12794
EntryNameHYAL1_HUMAN
FullNameHyaluronidase-1
TaxID9606
Evidenceevidence at protein level
Length435
SequenceStatuscomplete
DateCreated2005-10-25
DateModified2021-06-02

Ontological Relatives

GenesHYAL1

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0004415 hyalurononglucosaminidase activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005975 carbohydrate metabolic process
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0009615 response to virus
GO:0010634 positive regulation of epithelial cell migration
GO:0030207 chondroitin sulfate catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030213 hyaluronan biosynthetic process
GO:0030214 hyaluronan catabolic process
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031410 cytoplasmic vesicle
GO:0036117 hyaluranon cable
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043202 lysosomal lumen
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045927 positive regulation of growth
GO:0046677 response to antibiotic
GO:0046718 viral entry into host cell
GO:0050501 hyaluronan synthase activity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051216 cartilage development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0070062 extracellular exosome
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071467 cellular response to pH
GO:0071493 cellular response to UV-B
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900106 positive regulation of hyaluranon cable assembly

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR018155 HyaluronidaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
601492 OMIMMucopolysaccharidosis 9 (MPS9)A lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HYAL1_HUMANCO2A1_HUMANBioGRID, IntAct21988832 details