Entity Details

Primary name CLDN16
Entity type gene
Source Source Link

Details

PrimaryID10686
RefseqGeneNG_008149
SymbolCLDN16
Nameclaudin 16
Chromosome3
Location3q28
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCLD16_HUMAN

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006875 cellular metal ion homeostasis
GO:0007155 cell adhesion
GO:0007588 excretion
GO:0015095 magnesium ion transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0042802 identical protein binding
GO:0070830 bicellular tight junction assembly

Diseases

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Disease IDSourceNameDescription
248250 OMIMHypomagnesemia 3 (HOMG3)A progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
CLDN16CLDN19DIP, MINT19706394 22373575 details
CLDN16APPBioGRID21832049 details
CLDN16TJP1HPRD14628289 details