Entity Details

Primary name MASP2
Entity type gene
Source Source Link

Details

PrimaryID10747
RefseqGeneNG_007289
SymbolMASP2
NameMBL associated serine protease 2
Chromosome1
Location1p36.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-16
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMASP2_HUMAN

GO terms

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GOName
GO:0001855 complement component C4b binding
GO:0001867 complement activation, lectin pathway
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008233 peptidase activity
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0070062 extracellular exosome

Diseases

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Disease IDSourceNameDescription
613791 OMIMMASP2 deficiency (MASPD)A disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

9 interactions

InteractorPartnerSourcesPublicationsLink
MASP2MASP2BioGRID, HPRD, IntAct, UniProt11290788 15117939 23785123 888800000002 details
MASP2MBL2BioGRID, HPRD, IntAct, UniProt10878362 11290788 15117939 888800000002 details
MASP2FCN2BioGRID, HPRD, IntAct, UniProt12421953 15117939 23785123 details
MASP2C4ABioGRID, IntAct22071314 23785123 888800000002 details
MASP2SERPING1BioGRID, HPRD10946292 details
MASP2FCN1UniProt16116205 details
MASP2MASP1BioGRID, IntAct10878362 23785123 details
MASP2C4B_2IntAct22071314 23785123 details
MASP2C4BIntAct22071314 23785123 details