Entity Details

Primary name STK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13043
EntryNameSTK4_HUMAN
FullNameSerine/threonine-protein kinase 4
TaxID9606
Evidenceevidence at protein level
Length487
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSTK4

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000902 cell morphogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001841 neural tube formation
GO:0001934 positive regulation of protein phosphorylation
GO:0003157 endocardium development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0016604 nuclear body
GO:0018105 peptidyl-serine phosphorylation
GO:0030216 keratinocyte differentiation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043539 protein serine/threonine kinase activator activity
GO:0045600 positive regulation of fat cell differentiation
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060800 regulation of cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011524 SARAH domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR024205 Mst1 SARAH domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614868 OMIMT-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations (TIIAC)A primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T-cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, autoimmune manifestations, and cardiac malformations, including atrial septal defect. The disease is caused by variants affecting the gene represented in this entry.

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
STK4_HUMANRASF5_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections11864565 15109305 16892067 17517604 20562859 20920251 23455922 24255178 24366813 24981860 details
STK4_HUMANRASF1_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections14729613 15109305 17598981 20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 26578655 28205554 28514442 details
STK4_HUMANSTK4_HUMANBioGRID, DIP, HPRD, IntAct11278782 12223493 17517604 20562859 21572393 22863277 23386615 26578655 28205554 8702870 details
STK4_HUMANSAV1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections16930133 17517604 20562859 20920251 23386615 23455922 24255178 24366813 24981860 25692647 26186194 27173435 28514442 30266805 unassigned1312 details
STK4_HUMANAKT1_HUMANBioGRID, MINT17932490 details
STK4_HUMANRASF2_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 28514442 details
STK4_HUMANRASF3_HUMANBioGRID, IntAct, Molecular Connections20920251 23455922 24255178 24366813 details
STK4_HUMANRASF4_HUMANBioGRID, IntAct, Molecular Connections20562859 20920251 23455922 24366813 details
STK4_HUMANRASF6_HUMANBioGRID, IntAct, Molecular Connections20920251 24366813 26186194 28514442 details
STK4_HUMANSTK3_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26344197 28205554 details
STK4_HUMANGBRAP_HUMANBioGRID, IntAct20562859 31857374 details
STK4_HUMANGBRL1_HUMANIntAct20562859 details
STK4_HUMANGBRL2_HUMANIntAct20562859 details
STK4_HUMANMLP3B_HUMANBioGRID, IntAct20562859 31857374 details
STK4_HUMANMLP3C_HUMANIntAct20562859 details
STK4_HUMANIL2RG_HUMANBioGRID, IntAct21988832 details
STK4_HUMANMOB1A_HUMANBioGRID, I2D, IntAct21516123 23386615 24255178 31941533 details
STK4_HUMANMOB1B_HUMANBioGRID, IntAct22863277 24255178 details
STK4_HUMANSLMAP_HUMANBioGRID, IntAct23386615 24255178 24366813 details
STK4_HUMANP52K_HUMANBioGRID, HPRD, IntAct12384512 24255178 details
STK4_HUMANPRDX1_HUMANIntAct23386615 details
STK4_HUMANPIHD1_HUMANIntAct23386615 details
STK4_HUMANPARVB_HUMANIntAct23386615 details
STK4_HUMANUBB_HUMANIntAct23386615 details
STK4_HUMANCSRP2_HUMANIntAct23386615 details
STK4_HUMANSPA5L_HUMANIntAct23386615 details
STK4_HUMANSODM_HUMANIntAct23386615 details
STK4_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
STK4_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
STK4_HUMANFOXO1_HUMANDIP18786403 details
STK4_HUMANH2B2E_HUMANBioGRID12757711 21572393 details
STK4_HUMANSIR1_HUMANBioGRID21212262 details
STK4_HUMANABL1_HUMANBioGRID21715626 details
STK4_HUMANH2AX_HUMANBioGRID20921231 details
STK4_HUMANNEDD4_HUMANBioGRID19953087 details
STK4_HUMANSMS1_HUMANBioGRID22863277 details
STK4_HUMANLATS2_HUMANBioGRID24255178 26578655 26898830 30266805 30865227 details
STK4_HUMANDAXX_HUMANBioGRID21572393 details
STK4_HUMANKEAP1_HUMANBioGRID30765703 details
STK4_HUMANRNF31_HUMANBioGRID30901564 details
STK4_HUMANMARK2_HUMANBioGRID31080060 details
STK4_HUMANOGT1_HUMANBioGRID32994395 details
STK4_HUMAN1433G_HUMANIntAct17353931 details
STK4_HUMANP53_HUMANBioGRID, HPRD, IntAct12384512 12942774 25241761 details
STK4_HUMANCASP3_HUMANBioGRID, HPRD, IntAct11278283 11278782 25241761 9545236 details
STK4_HUMANLATS1_HUMANHPRD, IntAct15688006 24012335 details
STK4_HUMANHSP7C_HUMANBioGRID, IntAct23386615 26657153 details
STK4_HUMANKIF3B_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANKIF3C_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANAKA12_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANDYRK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANFYN_HUMANIntAct31413325 details
STK4_HUMANCNKR1_HUMANBioGRID, HPRD15075335 details
STK4_HUMANFOXO3_HUMANBioGRID21715626 details
STK4_HUMANCT2NL_HUMANBioGRID24255178 details
STK4_HUMANFBW1B_HUMANBioGRID25332235 25515538 25900982 details
STK4_HUMANLTOR5_HUMANBioGRID26657153 details
STK4_HUMANHDAC6_HUMANBioGRID26657153 details
STK4_HUMANCUL7_HUMANBioGRID29632206 32252802 details
STK4_HUMANTRAF6_HUMANBioGRID30673917 details
STK4_HUMANAMOT_HUMANBioGRID30266805 details
STK4_HUMANCASA1_HUMANHPRD7665586 details
STK4_HUMANMBP_HUMANHPRD7665586 details