Entity Details

Primary name CHRM2
Entity type gene
Source Source Link

Details

PrimaryID1129
RefseqGeneNG_011846
SymbolCHRM2
Namecholinergic receptor muscarinic 2
Chromosome7
Location7q33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1990-12-10
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsACM2_HUMAN

GO terms

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GOName
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0008016 regulation of heart contraction
GO:0009615 response to virus
GO:0016021 integral component of membrane
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0061024 membrane organization
GO:1990763 arrestin family protein binding

Diseases

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Disease IDSourceNameDescription
608516 OMIMMajor depressive disorder (MDD)A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Disease susceptibility is associated with variants affecting the gene represented in this entry.