Entity Details

Primary name KLF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13351
EntryNameKLF1_HUMAN
FullNameKrueppel-like factor 1
TaxID9606
Evidenceevidence at protein level
Length362
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesKLF1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030218 erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0060135 maternal process involved in female pregnancy
GO:1901653 cellular response to peptide

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR031784 Krueppel-like factor 1, transactivation domain 2DomainDomain
IPR031785 Krueppel-like factor 1FamilyFamily
IPR031786 Krueppel-like factor 1, transactivation domain 1DomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613673 OMIMAnemia, congenital dyserythropoietic, 4 (CDAN4)A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
KLF1_HUMANUBC_HUMANBioGRID, MINT16579989 24139988 details
KLF1_HUMANPATZ1_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANRU1C_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANTIAR_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANPRR3_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANRBM4B_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANFBLN4_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANC1QBP_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANGYS1_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANPCBP1_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANRBM10_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANRBPS2_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANHNRPK_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANHNRPF_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANVP37C_HUMANBioGRID, IntAct32296183 details
KLF1_HUMANTF2H1_HUMANBioGRID, DIP21670263 details
KLF1_HUMANCBP_HUMANBioGRID, DIP11259590 21670263 details
KLF1_HUMANEP300_HUMANBioGRID, DIP21670263 details
KLF1_HUMANARI1A_HUMANBioGRID11018012 details
KLF1_HUMANSMCA4_HUMANBioGRID11018012 details
KLF1_HUMANSMRC2_HUMANBioGRID11018012 details
KLF1_HUMANSMRC1_HUMANBioGRID, HPRD11018012 details
KLF1_HUMANSMRD1_HUMANBioGRID11018012 details
KLF1_HUMANSMCE1_HUMANBioGRID11018012 details
KLF1_HUMANSNF5_HUMANBioGRID, HPRD11018012 11259590 details
KLF1_HUMANCSK22_HUMANBioGRID, HPRD9722526 details
KLF1_HUMANCSK21_HUMANBioGRID, HPRD9722526 details
KLF1_HUMANFLI1_HUMANBioGRID, HPRD12556498 details
KLF1_HUMANHDAC1_HUMANBioGRID11287616 15542849 details
KLF1_HUMANSIN3A_HUMANBioGRID15542849 details
KLF1_HUMANKAPCA_HUMANHPRD9722526 details