Entity Details

Primary name PLD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13393
EntryNamePLD1_HUMAN
FullNamePhospholipase D1
TaxID9606
Evidenceevidence at protein level
Length1074
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPLD1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0004630 phospholipase D activity
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006654 phosphatidic acid biosynthetic process
GO:0006935 chemotaxis
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0016020 membrane
GO:0016042 lipid catabolic process
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0031902 late endosome membrane
GO:0032534 regulation of microvillus assembly
GO:0035091 phosphatidylinositol binding
GO:0035579 specific granule membrane
GO:0043312 neutrophil degranulation
GO:0045727 positive regulation of translation
GO:0048017 inositol lipid-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0048870 cell motility
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0070821 tertiary granule membrane
GO:0098693 regulation of synaptic vesicle cycle
GO:0098981 cholinergic synapse

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Golgi apparatus membrane
Late endosome membrane

Domains

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DomainNameCategoryType
IPR001683 Phox homologyDomainDomain
IPR001736 Phospholipase D/TransphosphatidylaseDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015679 Phospholipase D familyFamilyFamily
IPR016555 Phospholipase D, eukaryotic typeFamilyFamily
IPR025202 Phospholipase D-like domainDomainDomain
IPR036871 PX domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
212093 OMIMCardiac valvular defect, developmental (CVDD)An autosomal recessive form of congenital heart defects, characterized by valvular malformations involving the pulmonic, tricuspid and mitral valves. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB05301 LAX-101Drugbanksmall molecule
DB09031 MiltefosineDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
PLD1_HUMANPKN3_HUMANHPRD, MINT11259428 details
PLD1_HUMANCOF1_HUMANMINT17853892 details
PLD1_HUMANSTXB1_HUMANHPRD, MINT14744865 19323535 details
PLD1_HUMANPLCG1_HUMANMINT19323535 details
PLD1_HUMANRHEB_HUMANBioGRID, DIP18550814 details
PLD1_HUMANSPIR1_HUMANIntAct32814053 details
PLD1_HUMANESRP1_HUMANIntAct32814053 details
PLD1_HUMANTP53B_HUMANIntAct32814053 details
PLD1_HUMANTFE2_HUMANIntAct32814053 details
PLD1_HUMANFANCG_HUMANIntAct32814053 details
PLD1_HUMANLIAT1_HUMANIntAct32814053 details
PLD1_HUMANINCA1_HUMANIntAct32814053 details
PLD1_HUMANASCL4_HUMANIntAct32814053 details
PLD1_HUMANSYNCI_HUMANIntAct32814053 details
PLD1_HUMANA4_HUMANIntAct32814053 details
PLD1_HUMANSRC_HUMANBioGRID12697812 details
PLD1_HUMANRHOA_HUMANBioGRID, HPRD11311142 12593858 9565577 details
PLD1_HUMANAMPH_HUMANBioGRID10764771 details
PLD1_HUMANBIN1_HUMANBioGRID10764771 details
PLD1_HUMANSYUA_HUMANBioGRID, HPRD11821392 details
PLD1_HUMANPEA15_HUMANBioGRID, HPRD10926929 18541525 24710276 details
PLD1_HUMANPKN1_HUMANBioGRID, HPRD11259428 details
PLD1_HUMANRALA_HUMANBioGRID, HPRD9207251 9688545 details
PLD1_HUMANCDC42_HUMANBioGRID, HPRD10747870 details
PLD1_HUMANACTG_HUMANBioGRID, HPRD12388543 details
PLD1_HUMANHIF1A_HUMANBioGRID25361009 details
PLD1_HUMANEGLN1_HUMANBioGRID25361009 details
PLD1_HUMANVHL_HUMANBioGRID25361009 details
PLD1_HUMANARI1_HUMANHPRD10926929 details
PLD1_HUMANKS6A3_HUMANDIP18550821 details
PLD1_HUMANKPCA_HUMANBioGRID, HPRD10441128 12839565 details
PLD1_HUMANARF1_HUMANBioGRID, HPRD26344197 9688545 details
PLD1_HUMANARF6_HUMANBioGRID, HPRD12379803 34079125 details
PLD1_HUMANPLCG2_HUMANBioGRID16923831 details
PLD1_HUMANRHOG_HUMANHPRD12376551 details
PLD1_HUMANRAC1_HUMANHPRD11950936 details
PLD1_HUMANPLD1_HUMANHPRD12376551 details
PLD1_HUMANPI51A_HUMANHPRD11032811 details
PLD1_HUMANACTS_HUMANHPRD12388543 details
PLD1_HUMANEGFR_HUMANHPRD11459228 details
PLD1_HUMANCAV1_HUMANHPRD10090765 12429840 details
PLD1_HUMANACTB_HUMANHPRD11373276 details