Entity Details

Primary name ORC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13415
EntryNameORC1_HUMAN
FullNameOrigin recognition complex subunit 1
TaxID9606
Evidenceevidence at protein level
Length861
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesORC1

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000781 chromosome, telomeric region
GO:0000808 origin recognition complex
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0016887 ATP hydrolysis activity
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0036388 pre-replicative complex assembly
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001025 Bromo adjacent homology (BAH) domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR015163 Cdc6, C-terminalDomainDomain
IPR020793 Origin recognition complex, subunit 1FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR041083 AAA lid domainDomainDomain
IPR043151 Bromo adjacent homology (BAH) domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
224690 OMIMMeier-Gorlin syndrome 1 (MGORS1)A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
ORC1_HUMANCDC6_HUMANBioGRID, HPRD, IntAct12614612 12912926 15232106 9566895 details
ORC1_HUMANCDC5L_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANMCM5_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANCDT1_HUMANBioGRID, HPRD, IntAct15232106 details
ORC1_HUMANORC5_HUMANBioGRID, DIP, HPRD, IntAct12614612 15232106 16549788 17716973 22398447 26496610 31160578 details
ORC1_HUMANORC2_HUMANBioGRID, DIP, HPRD, IntAct11323433 11779870 11931757 12614612 15232106 16549788 17716973 20850016 22398447 26496610 31160578 details
ORC1_HUMANORC3_HUMANBioGRID, DIP, HPRD, IntAct15232106 16549788 17716973 22398447 26496610 31160578 details
ORC1_HUMANCDK2_HUMANBioGRID, HPRD, IntAct11931757 31160578 details
ORC1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct11931757 31160578 details
ORC1_HUMANTERF2_HUMANBioGRID, MINT16799465 18761675 31160578 details
ORC1_HUMANABL1_HUMANIntAct17474147 details
ORC1_HUMANFYN_HUMANIntAct17474147 details
ORC1_HUMANTS101_HUMANIntAct19549727 details
ORC1_HUMANORC4_HUMANBioGRID, DIP, IntAct12614612 16549788 17716973 26496610 31160578 details
ORC1_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
ORC1_HUMANHMGA1_HUMANDIP18234858 details
ORC1_HUMANCBX5_HUMANDIP20689044 details
ORC1_HUMANMCM2_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANMCM7_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANCDC7_HUMANBioGRID, HPRD12614612 details
ORC1_HUMANMCM4_HUMANBioGRID12614612 details
ORC1_HUMANMCM6_HUMANBioGRID12614612 details
ORC1_HUMANDBF4A_HUMANBioGRID12614612 details
ORC1_HUMANCDC45_HUMANBioGRID12614612 details
ORC1_HUMANRFA2_HUMANBioGRID12614612 details
ORC1_HUMANKAT7_HUMANBioGRID, HPRD10438470 details
ORC1_HUMANGOGA2_HUMANBioGRID25416956 details
ORC1_HUMANRB_HUMANBioGRID21085491 details
ORC1_HUMANCCNA2_HUMANBioGRID, IntAct11931757 26186194 26496610 28514442 31160578 details
ORC1_HUMANUBB_HUMANIntAct11931757 details
ORC1_HUMANLRWD1_HUMANBioGRID, IntAct26496610 31160578 details
ORC1_HUMANXRCC5_HUMANBioGRID12393188 31160578 details
ORC1_HUMANMGMT_HUMANBioGRID16226712 details
ORC1_HUMANOBI1_HUMANBioGRID31160578 details
ORC1_HUMANXPO1_HUMANHPRD11716535 details