Entity Details

Primary name KCC2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13554
EntryNameKCC2B_HUMAN
FullNameCalcium/calmodulin-dependent protein kinase type II subunit beta
TaxID9606
Evidenceevidence at protein level
Length666
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCAMK2B

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0003779 actin binding
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010976 positive regulation of neuron projection development
GO:0014733 regulation of skeletal muscle adaptation
GO:0030666 endocytic vesicle membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0045202 synapse
GO:0046777 protein autophosphorylation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0051823 regulation of synapse structural plasticity
GO:0051924 regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060998 regulation of dendritic spine development
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0090129 positive regulation of synapse maturation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:2000310 regulation of NMDA receptor activity
GO:2001222 regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR032710 NTF2-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617799 OMIMMental retardation, autosomal dominant 54 (MRD54)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07168 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
KCC2B_HUMANKCC2A_HUMANBioGRID, IntAct17353931 27173435 29426014 32296183 unassigned1312 details
KCC2B_HUMANATX1_HUMANBioGRID, IntAct23275563 details
KCC2B_HUMANRFOX2_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANBACH_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANKR10B_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANSMYD3_HUMANBioGRID, IntAct21988832 details
KCC2B_HUMANRAP2B_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANKR195_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANKR197_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANSPRY7_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANRL11_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANKPBB_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANMO4L1_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANAP5B1_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANMED18_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANPOP5_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANMD2L2_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANTTC5_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANRM11_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANKCC2B_HUMANBioGRID, DIP, HPRD, IntAct14565989 15604093 20668654 25416956 2842767 3417668 details
KCC2B_HUMANSEM4G_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANCCM2L_HUMANBioGRID, IntAct25416956 32296183 details
KCC2B_HUMANMO4L2_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANSYVC_HUMANIntAct32296183 details
KCC2B_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
KCC2B_HUMANKRT86_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANKCC2G_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANKR193_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANRPC3_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANPNKP_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANARSA_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANKCC2D_HUMANBioGRID, DIP, HPRD, IntAct16185778 20668654 28514442 29426014 32296183 details
KCC2B_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMAN1433B_HUMANBioGRID12619878 details
KCC2B_HUMANRXRG_HUMANBioGRID, HPRD15604093 details
KCC2B_HUMANTNPO3_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANZMYM5_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANPCNA_HUMANUniProt26030842 details
KCC2B_HUMANACTN4_HUMANBioGRID, HPRD11160423 details
KCC2B_HUMANTNPO2_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANDUS1L_HUMANBioGRID, IntAct32296183 details
KCC2B_HUMANMVP_HUMANBioGRID24722188 details
KCC2B_HUMANMGT5B_HUMANBioGRID25416956 details
KCC2B_HUMANKR109_HUMANBioGRID25416956 details
KCC2B_HUMANCK2N2_HUMANHPRD9724800 details
KCC2B_HUMANF1712_HUMANBioGRID25416956 details
KCC2B_HUMANCALM2_HUMANDIP20668654 details
KCC2B_HUMANMEOX2_HUMANBioGRID32296183 details
KCC2B_HUMANTHB_HUMANBioGRID, HPRD15604093 details
KCC2B_HUMANZBT32_HUMANBioGRID26871637 details
KCC2B_HUMANHS90B_HUMANIntAct22939624 details
KCC2B_HUMANFMR1_HUMANMINT21653829 details
KCC2B_HUMANFXR1_HUMANMINT21653829 details
KCC2B_HUMANSHAN3_HUMANMINT21653829 details
KCC2B_HUMANFXR2_HUMANMINT21653829 details
KCC2B_HUMANNMDE2_HUMANHPRD11306676 12147342 16436603 8940188 details
KCC2B_HUMANG3P_HUMANHPRD15199064 details
KCC2B_HUMANCO4A3_HUMANHPRD7758473 details
KCC2B_HUMANPLCB3_HUMANHPRD11325525 details
KCC2B_HUMANIP3KA_HUMANHPRD11468283 details
KCC2B_HUMANNMDE1_HUMANHPRD12147342 details
KCC2B_HUMANETS1_HUMANHPRD12475968 details