Entity Details

Primary name DENND1B
Entity type gene
Source Source Link

Details

PrimaryID163486
RefseqGene
SymbolDENND1B
NameDENN domain containing 1B
Chromosome1
Location1q31.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2002-01-25
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsDEN1B_HUMAN

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016607 nuclear speck
GO:0030136 clathrin-coated vesicle
GO:0031267 small GTPase binding
GO:0032456 endocytic recycling
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:1901981 phosphatidylinositol phosphate binding
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Diseases

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Disease IDSourceNameDescription
600807 OMIMAsthma (ASTHMA)The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. Disease susceptibility is associated with variants affecting the gene represented in this entry. Asthma susceptibility is probably caused by decreased TCR down-modulation and recycling in TH2 cells, causing prolonged TCR signaling and increased cytokine production in TH2 lymphocytes (PubMed:26774822).

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
DENND1BLNX1BioGRID, IntAct32296183 details
DENND1BSERPINA12BioGRID, IntAct26186194 28514442 details
DENND1BXPO1BioGRID26673895 details
DENND1BHNRNPLBioGRID28611215 details
DENND1BVIRMABioGRID29507755 details