Entity Details

Primary name CFD
Entity type gene
Source Source Link

Details

PrimaryID1675
RefseqGeneNG_007274
SymbolCFD
Namecomplement factor D
Chromosome19
Location19p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-12-10
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCFAD_HUMAN

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0007219 Notch signaling pathway
GO:0008236 serine-type peptidase activity
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Diseases

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Disease IDSourceNameDescription
613912 OMIMComplement factor D deficiency (CFDD)An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
CFDSERPINF2BioGRID, HPRD12080056 details
CFDHDHD2HPRD16169070 details
CFDCFDHPRD2023254 8289289 details
CFDALBBioGRID, IntAct15174051 details
CFDCFHR4IntAct22518841 details
CFDHNRNPH1BioGRID26760575 details