Entity Details

Primary name ITA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13683
EntryNameITA7_HUMAN
FullNameIntegrin alpha-7
TaxID9606
Evidenceevidence at protein level
Length1181
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesITGA7

GO terms

Show/Hide Table
GOName
GO:0005886 plasma membrane
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007517 muscle organ development
GO:0008305 integrin complex
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0034113 heterotypic cell-cell adhesion
GO:0035987 endodermal cell differentiation
GO:0046872 metal ion binding

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613204 OMIMMuscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. The disease is caused by variants affecting the gene represented in this entry.