Entity Details

Primary name DNASE1
Entity type gene
Source Source Link

Details

PrimaryID1773
RefseqGeneNG_009285
SymbolDNASE1
Namedeoxyribonuclease 1
Chromosome16
Location16p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-05-15
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDNAS1_HUMAN

GO terms

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GOName
GO:0000737 DNA catabolic process, endonucleolytic
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004530 deoxyribonuclease I activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0070062 extracellular exosome
GO:0070948 regulation of neutrophil mediated cytotoxicity

Diseases

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Disease IDSourceNameDescription
152700 OMIMSystemic lupus erythematosus (SLE)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry. Neutrophil extracellular traps (NETs) are impaired in patients suffering from SLE (PubMed:20439745). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20439745).

Interactions

5 interactions