Entity Details

Primary name F2
Entity type gene
Source Source Link

Details

PrimaryID2147
RefseqGeneNG_008953
SymbolF2
Namecoagulation factor II, thrombin
Chromosome11
Location11p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-07-29
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTHRB_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001530 lipopolysaccharide binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030307 positive regulation of cell growth
GO:0030449 regulation of complement activation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0042730 fibrinolysis
GO:0044267 cellular protein metabolic process
GO:0045861 negative regulation of proteolysis
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048712 negative regulation of astrocyte differentiation
GO:0050900 leukocyte migration
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051838 cytolysis by host of symbiont cells
GO:0051918 negative regulation of fibrinolysis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070053 thrombospondin receptor activity
GO:0070062 extracellular exosome
GO:0070945 neutrophil-mediated killing of gram-negative bacterium
GO:0072562 blood microparticle
GO:0090218 positive regulation of lipid kinase activity
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900182 positive regulation of protein localization to nucleus
GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process

Diseases

Show/Hide Table
Disease IDSourceNameDescription
188050 OMIMThrombophilia due to thrombin defect (THPH1)A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. The disease is caused by variants affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.
613679 OMIMFactor II deficiency (FA2D)A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. The disease is caused by variants affecting the gene represented in this entry.
614390 OMIMPregnancy loss, recurrent, 2 (RPRGL2)A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Disease susceptibility is associated with variants affecting the gene represented in this entry.
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
F2THBDBioGRID, HPRD, IntAct14691232 2544585 7615164 8663147 details
F2DDIT3BioGRID, IntAct21988832 details
F2F2RDIP, HPRD10644723 10978167 12563219 18250335 9058715 details
F2SERPINA5DIP, HPRD12878585 18362344 details
F2F8DIP, HPRD10350471 18492805 details
F2APPIntAct32814053 details
F2SERPINE1BioGRID, HPRD10543954 12709053 details
F2ITGA2BBioGRID, HPRD11487023 details
F2CPB2BioGRID, HPRD10777524 8663147 details
F2SERPINB6BioGRID, HPRD7548163 8415716 9851866 details
F2F5BioGRID, HPRD10026263 9032460 details
F2SERPING1BioGRID, HPRD11460008 details
F2THBS1BioGRID, HPRD2435757 details
F2ST13BioGRID, HPRD11687574 details
F2MAPTBioGRID15542598 details
F2GP1BAHPRD, IntAct11024046 12855810 2933256 details
F2SERPINC1HPRD, IntAct11927130 15311269 3800906 7238875 details
F2FGABioGRID, HPRD, IntAct1587268 2133223 25241761 2742826 details
F2SPP1BioGRID, HPRD, IntAct11375993 25241761 details
F2SERPIND1BioGRID, HPRD12169660 2760054 details
F2PLATBioGRID10543954 details
F2PROCHPRD2544585 details
F2AMBPHPRD9183005 details
F2PROS1HPRD12490286 details
F2SERPINE2HPRD12106474 details
F2C6HPRD3192535 details
F2KNG1HPRD1652157 details
F2F9HPRD15039440 details
F2AANATHPRD11427721 details
F2SERPINB8HPRD9402754 details
F2F2RL2HPRD12732212 details
F2F2RL3HPRD12732212 details
F2AKR7A2HPRD9576847 details
F2HGFACHPRD8226803 details
F2F11HPRD1652157 details
F2PROZHPRD1872862 2040612 details
F2PLAUHPRD10996659 8428004 details
F2F2HPRD8071320 details
F2F2RL1HPRD10978167 details
F2IGFBP3HPRD7538844 8843739 details
F2GP5HPRD9129030 details
F2IGFBP5HPRD9528953 9883900 details
F2F13A1HPRD9546612 details
F2GGCXHPRD10556651 3944102 details
F2ALBBioGRID, IntAct15174051 details
F2C1QBPUniProt8900153 details
F2YWHAQIntAct28514442 details
F2CHAMP1BioGRID, MINT24981860 details
F2FN1BioGRID23750785 details
F2CGASBioGRID30471916 details
F2BIRC3BioGRID30948266 details
F2NUPR1BioGRID32780723 details
F2APOC3BioGRID24981860 details
F2F10BioGRID24981860 details