Entity Details

Primary name KGP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13976
EntryNameKGP1_HUMAN
FullNamecGMP-dependent protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length671
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPRKG1

GO terms

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GOName
GO:0001764 neuron migration
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005246 calcium channel regulator activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016358 dendrite development
GO:0019934 cGMP-mediated signaling
GO:0030036 actin cytoskeleton organization
GO:0030553 cGMP binding
GO:0030900 forebrain development
GO:0042802 identical protein binding
GO:0043087 regulation of GTPase activity
GO:0060087 relaxation of vascular associated smooth muscle
GO:0090331 negative regulation of platelet aggregation
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002374 cGMP-dependent kinaseFamilyFamily
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR031831 cGMP-dependent protein kinase, N-terminal coiled-coil domainDomainDomain
IPR035014 cGMP-dependent protein kinase, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615436 OMIMAortic aneurysm, familial thoracic 8 (AAT8)A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
KGP1_HUMANKGP1_HUMANDIP, UniProt20826808 27066748 details
KGP1_HUMANRBTN2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
KGP1_HUMANZN646_HUMANBioGRID, IntAct25416956 31515488 details
KGP1_HUMANF124A_HUMANBioGRID, IntAct25416956 31515488 details
KGP1_HUMANARHGF_HUMANBioGRID, IntAct32296183 details
KGP1_HUMANRBAK_HUMANBioGRID, IntAct32296183 details
KGP1_HUMANITPR1_HUMANBioGRID, DIP, HPRD10724174 18757735 8132598 details
KGP1_HUMANTRI54_HUMANBioGRID, IntAct31391242 details
KGP1_HUMANANPRA_HUMANBioGRID, HPRD12855709 details
KGP1_HUMANRGS2_HUMANBioGRID, HPRD14608379 details
KGP1_HUMANIRAG1_HUMANBioGRID, HPRD10724174 11309393 details
KGP1_HUMANMYPT2_HUMANBioGRID10567269 details
KGP1_HUMANMYPT1_HUMANBioGRID, HPRD10567269 details
KGP1_HUMANGTF2I_HUMANBioGRID, HPRD12082086 details
KGP1_HUMANTNNT1_HUMANBioGRID, HPRD10601315 details
KGP1_HUMANHDAC1_HUMANBioGRID12082111 details
KGP1_HUMANLYAM1_HUMANBioGRID15192100 details
KGP1_HUMANCREB1_HUMANBioGRID, HPRD11175347 8688081 9687510 9829964 details
KGP1_HUMANANXA7_HUMANBioGRID11278415 details
KGP1_HUMANMEP50_HUMANBioGRID23755100 details
KGP1_HUMANANDR_HUMANBioGRID23755100 details
KGP1_HUMANMEOX2_HUMANBioGRID32296183 details
KGP1_HUMANGKAP1_HUMANHPRD10671526 details
KGP1_HUMANFHOD1_HUMANHPRD15051728 details
KGP1_HUMANBMPR2_HUMANMINT19424179 details
KGP1_HUMANSMAD4_HUMANMINT19424179 details
KGP1_HUMANPDE5A_HUMANDIP, HPRD18757735 2168396 details
KGP1_HUMANRAF1_HUMANBioGRID, HPRD12237340 details
KGP1_HUMANOSTP_HUMANHPRD8663267 details
KGP1_HUMANKPCA_HUMANHPRD12609995 details
KGP1_HUMANRYR1_HUMANHPRD14532276 8380342 details
KGP1_HUMANPLCB3_HUMANHPRD11278298 details
KGP1_HUMANCRIP2_HUMANHPRD10681529 details
KGP1_HUMANSF01_HUMANHPRD10449420 details
KGP1_HUMANVASP_HUMANHPRD10851246 10922374 8182057 details
KGP1_HUMANCFTR_HUMANHPRD1377674 details
KGP1_HUMANLASP1_HUMANHPRD12571245 details
KGP1_HUMANPPR17_HUMANHPRD10051666 details
KGP1_HUMANSEPT3_HUMANHPRD15107017 details
KGP1_HUMANGBRR1_HUMANHPRD12175859 details
KGP1_HUMANTRPC3_HUMANHPRD14983059 details