Entity Details

Primary name F11
Entity type gene
Source Source Link

Details

PrimaryID2160
RefseqGeneNG_008051
SymbolF11
Namecoagulation factor XI
Chromosome4
Location4q35.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-13
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFA11_HUMAN

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008201 heparin binding
GO:0016020 membrane
GO:0031639 plasminogen activation
GO:0042802 identical protein binding
GO:0051919 positive regulation of fibrinolysis
GO:0070009 serine-type aminopeptidase activity
GO:0070062 extracellular exosome

Diseases

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Disease IDSourceNameDescription
612416 OMIMFactor XI deficiency (FA11D)A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. The disease is caused by variants affecting the gene represented in this entry.

Interactions

14 interactions