Entity Details

Primary name FCGR3A
Entity type gene
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Details

PrimaryID2214
RefseqGeneNG_009066
SymbolFCGR3A
NameFc fragment of IgG receptor IIIa
Chromosome1
Location1q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFCG3A_HUMAN

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004888 transmembrane signaling receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0018149 peptide cross-linking
GO:0019864 IgG binding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0050776 regulation of immune response
GO:0070062 extracellular exosome

Diseases

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Disease IDSourceNameDescription
615707 OMIMImmunodeficiency 20 (IMD20)A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). The disease is caused by variants affecting the gene represented in this entry.