Entity Details

Primary name SCRIB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14160
EntryNameSCRIB_HUMAN
FullNameProtein scribble homolog
TaxID9606
Evidenceevidence at protein level
Length1630
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesSCRIB

GO terms

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GOName
GO:0001768 establishment of T cell polarity
GO:0001772 immunological synapse
GO:0001843 neural tube closure
GO:0001921 positive regulation of receptor recycling
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0008283 cell population proliferation
GO:0014069 postsynaptic density
GO:0016323 basolateral plasma membrane
GO:0016477 cell migration
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030683 mitigation of host immune response by virus
GO:0030859 polarized epithelial cell differentiation
GO:0032729 positive regulation of interferon-gamma production
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035089 establishment of apical/basal cell polarity
GO:0039563 suppression by virus of host STAT1 activity
GO:0039564 suppression by virus of host STAT2 activity
GO:0043065 positive regulation of apoptotic process
GO:0043113 receptor clustering
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045296 cadherin binding
GO:0045930 negative regulation of mitotic cell cycle
GO:0046007 negative regulation of activated T cell proliferation
GO:0050918 positive chemotaxis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0070062 extracellular exosome
GO:0071896 protein localization to adherens junction
GO:0090630 activation of GTPase activity
GO:0097120 receptor localization to synapse
GO:0098609 cell-cell adhesion
GO:0098793 presynapse
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
182940 OMIMNeural tube defects (NTD)Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. The disease is caused by variants affecting the gene represented in this entry.

Interactions

94 interactions

InteractorPartnerSourcesPublicationsLink
SCRIB_HUMANEXOSX_HUMANBioGRID, HPRD, IntAct15231747 details
SCRIB_HUMANZO2_HUMANBioGRID, HPRD, MINT15975580 34079125 details
SCRIB_HUMANARHG7_HUMANBioGRID, HPRD, IntAct, MINT15182672 15975580 19041750 19555689 21132015 24550280 26617989 details
SCRIB_HUMANTRIP6_HUMANHPRD, MINT16137684 details
SCRIB_HUMANUBE3A_HUMANBioGRID, MINT11027293 16482544 details
SCRIB_HUMANAPC_HUMANBioGRID, IntAct, MINT16611247 30126976 details
SCRIB_HUMANTS101_HUMANIntAct19549727 details
SCRIB_HUMANCRCM_HUMANIntAct, MINT19555689 29144123 30126976 details
SCRIB_HUMANMK03_HUMANBioGRID, I2D20622900 details
SCRIB_HUMANMK01_HUMANI2D20622900 details
SCRIB_HUMANS6A12_HUMANIntAct, MINT21525870 24550280 details
SCRIB_HUMANWWTR1_HUMANIntAct22078877 30126976 details
SCRIB_HUMANARHG8_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANKCNA5_HUMANMINT24550280 details
SCRIB_HUMANVWCE_HUMANMINT24550280 details
SCRIB_HUMANDNM1L_HUMANMINT24550280 details
SCRIB_HUMANPKP4_HUMANBioGRID, IntAct, MINT24550280 30126976 details
SCRIB_HUMANNXPE2_HUMANMINT24550280 details
SCRIB_HUMANCTND2_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANZSWM1_HUMANMINT24550280 details
SCRIB_HUMANATD2B_HUMANMINT24550280 details
SCRIB_HUMANADA1D_HUMANIntAct, MINT24550280 26617989 27382054 details
SCRIB_HUMANMK12_HUMANBioGRID, IntAct, MINT24550280 30126976 details
SCRIB_HUMANSO1C1_HUMANMINT24550280 details
SCRIB_HUMANRBP1_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANGCYA2_HUMANBioGRID, IntAct, MINT24550280 30126976 details
SCRIB_HUMANADA22_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANKCNB2_HUMANMINT24550280 details
SCRIB_HUMANMRP4_HUMANMINT24550280 details
SCRIB_HUMANCTNB1_HUMANBioGRID, MINT24550280 34079125 details
SCRIB_HUMANMET_HUMANMINT24550280 details
SCRIB_HUMANDLK2_HUMANMINT24550280 details
SCRIB_HUMANANR50_HUMANMINT24550280 details
SCRIB_HUMANS15A5_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANF189B_HUMANMINT24550280 details
SCRIB_HUMANRPR1B_HUMANMINT24550280 details
SCRIB_HUMANTMIG1_HUMANMINT24550280 details
SCRIB_HUMANSTAR8_HUMANMINT24550280 details
SCRIB_HUMANZN563_HUMANMINT24550280 details
SCRIB_HUMANS4A4_HUMANMINT24550280 details
SCRIB_HUMANNR2E1_HUMANMINT24550280 details
SCRIB_HUMANLNX1_HUMANMINT24550280 details
SCRIB_HUMANKCJ12_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANKCNJ4_HUMANIntAct, MINT24550280 30126976 details
SCRIB_HUMANACTN1_HUMANMINT24550280 details
SCRIB_HUMANACTN2_HUMANMINT24550280 details
SCRIB_HUMANACTN3_HUMANMINT24550280 details
SCRIB_HUMANACTN4_HUMANMINT24550280 details
SCRIB_HUMANTSHR_HUMANBioGRID, UniProt15775968 details
SCRIB_HUMANC5AR2_HUMANBioGRID, MINT28298427 details
SCRIB_HUMANKS6A2_HUMANBioGRID, IntAct29144123 30126976 31678930 details
SCRIB_HUMANKS6A1_HUMANIntAct30126976 details
SCRIB_HUMANTANC1_HUMANIntAct30126976 details
SCRIB_HUMANCPNE8_HUMANIntAct30126976 details
SCRIB_HUMANAT2B2_HUMANIntAct30126976 details
SCRIB_HUMANFAKD5_HUMANIntAct30126976 details
SCRIB_HUMANF163B_HUMANIntAct30126976 details
SCRIB_HUMANMELT_HUMANIntAct30126976 details
SCRIB_HUMANWTIP_HUMANIntAct30126976 details
SCRIB_HUMANAT2B1_HUMANIntAct30126976 details
SCRIB_HUMANCRFR1_HUMANIntAct30126976 details
SCRIB_HUMANFRPD4_HUMANIntAct30126976 details
SCRIB_HUMANCLTR2_HUMANIntAct30126976 details
SCRIB_HUMANYAP1_HUMANIntAct30126976 details
SCRIB_HUMANPRDX5_HUMANIntAct30126976 details
SCRIB_HUMANTBCD8_HUMANIntAct30126976 details
SCRIB_HUMAN5HT2C_HUMANIntAct30126976 details
SCRIB_HUMANNMDE2_HUMANIntAct30126976 details
SCRIB_HUMANFRPD1_HUMANIntAct30126976 details
SCRIB_HUMANMOT2_HUMANIntAct30126976 details
SCRIB_HUMANOR5F1_HUMANIntAct30126976 details
SCRIB_HUMANCSN1_HUMANIntAct30126976 details
SCRIB_HUMANASND1_HUMANIntAct30126976 details
SCRIB_HUMANARHGG_HUMANBioGRID, IntAct30126976 32203420 details
SCRIB_HUMANPD2R_HUMANIntAct30126976 details
SCRIB_HUMANAKAP1_HUMANIntAct30126976 details
SCRIB_HUMANHTR5B_HUMANIntAct30126976 details
SCRIB_HUMANXKR4_HUMANIntAct30126976 details
SCRIB_HUMANUT1_HUMANIntAct30126976 details
SCRIB_HUMANKCNJ2_HUMANIntAct30126976 details
SCRIB_HUMANS4A7_HUMANIntAct30126976 details
SCRIB_HUMANMOT4_HUMANIntAct30126976 details
SCRIB_HUMANKPCA_HUMANBioGRID20622900 details
SCRIB_HUMANOGT1_HUMANBioGRID32994395 details
SCRIB_HUMANM3K3_HUMANIntAct14743216 details
SCRIB_HUMANGIT1_HUMANIntAct, MINT15975580 19041750 26617989 details
SCRIB_HUMANPHLP1_HUMANBioGRID, IntAct, MINT19615732 21701506 24145035 details
SCRIB_HUMANCADH1_HUMANBioGRID, MINT21701506 25468996 details
SCRIB_HUMANDAA11_HUMANBioGRID, IntAct25036637 28514442 details
SCRIB_HUMANSSR3_HUMANBioGRID19071123 details
SCRIB_HUMANRN146_HUMANBioGRID27521426 details
SCRIB_HUMANMUSK_HUMANBioGRID20463225 details
SCRIB_HUMANSTX4_HUMANBioGRID, HPRD18793635 34079125 details
SCRIB_HUMANLPP_HUMANHPRD16137684 details