Entity Details

Primary name FOXO1
Entity type gene
Source Source Link

Details

PrimaryID2308
RefseqGeneNG_023244
SymbolFOXO1
Nameforkhead box O1
Chromosome13
Location13q14.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-04
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFOXO1_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001659 temperature homeostasis
GO:0001678 cellular glucose homeostasis
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008013 beta-catenin binding
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051721 protein phosphatase 2A binding
GO:0070166 enamel mineralization
GO:0070301 cellular response to hydrogen peroxide
GO:0070417 cellular response to cold
GO:0070542 response to fatty acid
GO:0071455 cellular response to hyperoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0097009 energy homeostasis
GO:1902617 response to fluoride
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:2000074 regulation of type B pancreatic cell development

Diseases

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Disease IDSourceNameDescription
268220 OMIMRhabdomyosarcoma 2 (RMS2)A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 and translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Interactions

89 interactions

InteractorPartnerSourcesPublicationsLink
FOXO1ESR1BioGRID, HPRD, IntAct11353774 11435445 22266855 details
FOXO1CDK1IntAct18408765 details
FOXO1ARBioGRID, HPRD, IntAct12482965 17202144 details
FOXO1YWHAZBioGRID, HPRD, IntAct, MINT11237865 28205554 28514442 details
FOXO1FHL2BioGRID, HPRD, UniProt15692560 details
FOXO1CREBBPBioGRID, HPRD, MINT, UniProt10973497 15220471 16154098 24419059 25609649 details
FOXO1AKT1BioGRID, DIP, HPRD, IntAct10358014 10358075 16076959 18786403 25241761 31844113 details
FOXO1SETBioGRID, MINT24983498 27626385 details
FOXO1EP300BioGRID, MINT11896584 15890677 18786403 24419059 25609649 details
FOXO1YWHAGBioGRID, HPRD, IntAct11237865 28205554 28514442 details
FOXO1STK4DIP18786403 details
FOXO1ETS1IntAct24419615 details
FOXO1TSC2BioGRID17077083 details
FOXO1CEBPBBioGRID, HPRD11893744 details
FOXO1HOXA5BioGRID, HPRD12163409 details
FOXO1HNF4ABioGRID, HPRD12519792 19740748 details
FOXO1PARP1BioGRID19281796 details
FOXO1LRPPRCBioGRID17050673 details
FOXO1SKP2BioGRID15668399 19686743 28802579 30535125 details
FOXO1SIRT2BioGRID15220471 20543840 24419059 details
FOXO1MDM2BioGRID19321440 27412556 details
FOXO1RARABioGRID, HPRD11353774 details
FOXO1MST1BioGRID18786403 details
FOXO1NCOA1BioGRID10973497 details
FOXO1PIK3R3BioGRID25814554 details
FOXO1TNS2BioGRID25814554 details
FOXO1PRKACABioGRID21177856 details
FOXO1PITX1BioGRID24065703 details
FOXO1EHMT2BioGRID30535125 details
FOXO1DACH1BioGRID28205554 details
FOXO1SFNBioGRID28205554 details
FOXO1NEDD4LBioGRID31844113 details
FOXO1CTNNB1HPRD15905404 details
FOXO1PPARGHPRD12966085 details
FOXO1SIRT1BioGRID, DIP, HPRD, UniProt15220471 15692560 16154098 18235501 22013015 details
FOXO1GSK3BBioGRID, HPRD, IntAct11980723 25241761 details
FOXO1SMAD4BioGRID, HPRD, IntAct15084259 details
FOXO1YWHAQBioGRID, IntAct24419059 28514442 details
FOXO1YWHABBioGRID, IntAct16919273 28514442 details
FOXO1SMAD3BioGRID, HPRD15084259 details
FOXO1COP1BioGRID18815134 details
FOXO1HOXA11BioGRID19727442 details
FOXO1PMLBioGRID16154098 details
FOXO1ATG7BioGRID20543840 22622204 23640897 30689742 details
FOXO1STUB1BioGRID19483080 details
FOXO1NLKBioGRID20874444 details
FOXO1FSHRBioGRID17030088 details
FOXO1IRF3BioGRID23532851 details
FOXO1CRY1BioGRID27412556 28790135 details
FOXO1SIRT7BioGRID28655758 details
FOXO1ATMBioGRID27559048 details
FOXO1MYH9BioGRID31754475 details
FOXO1SAMD4BBioGRID29395067 details
FOXO1FOXG1HPRD15084259 details
FOXO1THRBHPRD11353774 details
FOXO1HOXA10HPRD12493691 details
FOXO1SRCHPRD10973497 details
FOXO1G6PC1HPRD11672436 details
FOXO1PAK1HPRD10358014 12560069 details
FOXO1DYRK1AHPRD11311120 details
FOXO1CCNB1BioGRID, IntAct18408765 25241761 details
FOXO1CDKN1ABioGRID, IntAct25241761 details
FOXO1SATB2BioGRID, MINT25609649 details
FOXO1DLX5BioGRID, MINT25609649 details
FOXO1FOXO4BioGRID, MINT25609649 details
FOXO1SMARCA4BioGRID, MINT25609649 details
FOXO1SATB1BioGRID, MINT25609649 details
FOXO1FOXO1BioGRID, MINT25609649 details
FOXO1HOXC13MINT25609649 details
FOXO1RECQLBioGRID, MINT25609649 details
FOXO1CUX1BioGRID, MINT25609649 details
FOXO1SNX17BioGRID, MINT25609649 details
FOXO1DNAJC9BioGRID, MINT25609649 details
FOXO1MORF4L2BioGRID, MINT25609649 details
FOXO1RB1BioGRID, MINT25609649 details
FOXO1SETD7BioGRID, MINT25609649 details
FOXO1YWHAHIntAct28514442 details
FOXO1NCLBioGRID, IntAct30021884 details
FOXO1PAX3BioGRID, MINT24981860 details
FOXO1XPO1BioGRID26673895 details
FOXO1HOXD13BioGRID25609649 details
FOXO1NTPCRBioGRID24981860 details
FOXO1COL1A1BioGRID24981860 details
FOXO1COL1A2BioGRID24981860 details
FOXO1HBBBioGRID24981860 details
FOXO1VCLBioGRID34079125 details
FOXO1BCL2L11IntAct18408765 details
FOXO1KLF2IntAct18713968 details
FOXO1VIRMABioGRID29507755 details