Entity Details

Primary name FLT1
Entity type gene
Source Source Link

Details

PrimaryID2321
RefseqGeneNG_012003
SymbolFLT1
Namefms related receptor tyrosine kinase 1
Chromosome13
Location13q12.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-10-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsVGFR1_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002548 monocyte chemotaxis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030335 positive regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
GO:0036332 placental growth factor-activated receptor activity
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048598 embryonic morphogenesis
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1990384 hyaloid vascular plexus regression

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
FLT1VEGFAbhf-ucl, BioGRID, HPRD, IntAct, matrixdb10543948 1312256 17051153 18593464 20660291 21596751 21939755 28514442 8621427 9393862 details
FLT1PGFbhf-ucl, BioGRID, HPRD, IntAct14684734 20660291 9452434 details
FLT1CBLBioGRID, MINT18273061 25387128 details
FLT1PTPRJMINT12771128 16893970 details
FLT1PIK3R1BioGRID, IntAct, MINT20805333 23397142 7657594 details
FLT1SRPK1BioGRID, IntAct23602568 details
FLT1PLCG1BioGRID, HPRD, IntAct11312102 23397142 9299537 9398617 9600074 details
FLT1PTPN11BioGRID, HPRD, IntAct23397142 25241761 9600074 details
FLT1HSPG2matrixdb21596751 details
FLT1SHC1BioGRID, HPRD10749680 details
FLT1KDRBioGRID, HPRD10865839 12796773 25387128 details
FLT1VEGFBBioGRID, HPRD10409677 9751730 details
FLT1SHC2BioGRID10749680 9790910 details
FLT1NEDD4BioGRID19953087 details
FLT1FLT1BioGRID, HPRD11513746 7657594 details
FLT1PLCG2HPRD9398617 details
FLT1ATRHPRD10749680 details
FLT1NCK1HPRD9600074 details
FLT1LDLRMINT17962812 details
FLT1PTPRBMINT22016384 details
FLT1ROBO4IntAct23063127 details
FLT1CRKHPRD, IntAct23397142 9722576 details
FLT1CTNNB1HPRD, IntAct12920240 23397142 details
FLT1PTK2IntAct23397142 details
FLT1HCKIntAct23397142 details
FLT1CRKLIntAct23397142 details
FLT1NRP1HPRD, IntAct10842181 23452854 details
FLT1LGALS1IntAct24529377 details
FLT1EEA1IntAct23799140 details
FLT1FYNHPRD, UniProt12509223 details
FLT1YES1HPRD, UniProt12509223 details
FLT1MICAL2BioGRID25601765 details
FLT1NRP2HPRD11278319 details
FLT1GRB2HPRD9722576 details
FLT1STAT1HPRD15703780 details
FLT1STAT3HPRD15703780 details
FLT1PTK2BHPRD11751905 details
FLT1TMEM245IntAct23063127 details
FLT1S100A9IntAct23063127 details
FLT1SOGA1IntAct23063127 details
FLT1CIP2AIntAct23063127 details
FLT1TMCO4IntAct23063127 details
FLT1ANXA2IntAct23063127 details
FLT1SERPINB12IntAct23063127 details
FLT1TMC4IntAct23063127 details
FLT1SCARB1IntAct23063127 details
FLT1PKMIntAct24606918 details
FLT1SCGB2A2BioGRID, IntAct28514442 details