Entity Details

Primary name PLCB1
Entity type gene
Source Source Link

Details

PrimaryID23236
RefseqGeneNG_028168
SymbolPLCB1
Namephospholipase C beta 1
Chromosome20
Location20p12.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-12-29
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPLCB1_HUMAN

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000785 chromatin
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005521 lamin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007613 memory
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0016042 lipid catabolic process
GO:0016607 nuclear speck
GO:0019899 enzyme binding
GO:0021987 cerebral cortex development
GO:0031965 nuclear membrane
GO:0032735 positive regulation of interleukin-12 production
GO:0032991 protein-containing complex
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0042802 identical protein binding
GO:0043647 inositol phosphate metabolic process
GO:0045444 fat cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046488 phosphatidylinositol metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048639 positive regulation of developmental growth
GO:0060466 activation of meiosis involved in egg activation
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0080154 regulation of fertilization
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1903140 regulation of establishment of endothelial barrier
GO:2000344 positive regulation of acrosome reaction
GO:2000438 negative regulation of monocyte extravasation
GO:2000560 positive regulation of CD24 production

Diseases

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Disease IDSourceNameDescription
613722 OMIMDevelopmental and epileptic encephalopathy 12 (DEE12)A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. The disease is caused by variants affecting the gene represented in this entry.

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
PLCB1SPTBN1BioGRID, IntAct20936779 details
PLCB1CTBP2BioGRID, IntAct25416956 details
PLCB1TFCP2BioGRID, IntAct25416956 details
PLCB1CTBP1BioGRID, IntAct25416956 details
PLCB1CEP76BioGRID, IntAct25416956 details
PLCB1TRPM7BioGRID, HPRD11941371 details
PLCB1GNAQBioGRID, HPRD11753430 12193606 16754659 details
PLCB1PLCB1BioGRID11753430 details
PLCB1GRK2BioGRID10567430 details
PLCB1SLC9A3R1BioGRID, HPRD10980202 12193606 details
PLCB1KRIT1BioGRID12821674 details
PLCB1GNA11BioGRID12193606 details
PLCB1GANBioGRID26460568 details
PLCB1SNCABioGRID15605986 details
PLCB1PRKCAHPRD11278470 details
PLCB1PRKCDHPRD11278470 details
PLCB1MAPK3HPRD11287604 details
PLCB1RGS12HPRD9651375 details
PLCB1RGS4HPRD11148035 details
PLCB1TRPC3HPRD15623527 details
PLCB1PARD3HPRD15782111 details
PLCB1PARD6AHPRD15782111 details
PLCB1MAPK1HPRD11481231 details
PLCB1BTN2A1BioGRID, IntAct26186194 28514442 details
PLCB1PTGER3BioGRID, IntAct26186194 28514442 details
PLCB1DEF8BioGRID, IntAct28514442 details
PLCB1LAMP1BioGRID, IntAct29568061 34079125 details
PLCB1PHB2BioGRID, IntAct30021884 details
PLCB1H1-1BioGRID, IntAct30021884 details
PLCB1PRNPBioGRID, UniProt29791485 details
PLCB1KISS1RIntAct18772143 details
PLCB1PCF11BioGRID22939629 details
PLCB1HRASBioGRID30639242 details
PLCB1KRASBioGRID30194290 30639242 34079125 details
PLCB1NRASBioGRID30194290 details
PLCB1NR3C1BioGRID31182584 details
PLCB1ARF6BioGRID34079125 details
PLCB1C11orf52BioGRID34079125 details
PLCB1LAMP2BioGRID34079125 details
PLCB1LYNBioGRID34079125 details
PLCB1RAB2ABioGRID34079125 details
PLCB1RAB35BioGRID34079125 details
PLCB1RHOBBioGRID34079125 details
PLCB1VIRMABioGRID29507755 details
PLCB1APEX1BioGRID28986522 details