Entity Details

Primary name DCTN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14203
EntryNameDCTN1_HUMAN
FullNameDynactin subunit 1
TaxID9606
Evidenceevidence at protein level
Length1278
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDCTN1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005938 cell cortex
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007097 nuclear migration
GO:0007399 nervous system development
GO:0007528 neuromuscular junction development
GO:0008017 microtubule binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010457 centriole-centriole cohesion
GO:0015630 microtubule cytoskeleton
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0021517 ventral spinal cord development
GO:0030286 dynein complex
GO:0030424 axon
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0034454 microtubule anchoring at centrosome
GO:0035371 microtubule plus-end
GO:0036498 IRE1-mediated unfolded protein response
GO:0042147 retrograde transport, endosome to Golgi
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045171 intercellular bridge
GO:0048156 tau protein binding
GO:0050905 neuromuscular process
GO:0051010 microtubule plus-end binding
GO:0051081 nuclear membrane disassembly
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0061744 motor behavior
GO:0070050 neuron cellular homeostasis
GO:0072686 mitotic spindle
GO:0090063 positive regulation of microtubule nucleation
GO:0097711 ciliary basal body-plasma membrane docking
GO:0099558 maintenance of synapse structure
GO:0099738 cell cortex region
GO:0120103 centriolar subdistal appendage
GO:1904398 positive regulation of neuromuscular junction development
GO:1905515 non-motile cilium assembly
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus envelope

Domains

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DomainNameCategoryType
IPR000938 CAP Gly-rich domainDomainDomain
IPR022157 Dynein associated proteinDomainDomain
IPR036859 CAP Gly-rich domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
168605 OMIMPerry syndrome (PERRYS)A neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. The disease is caused by variants affecting the gene represented in this entry.
607641 OMIMNeuronopathy, distal hereditary motor, 7B (HMN7B)A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. The disease is caused by variants affecting the gene represented in this entry.
105400 OMIMAmyotrophic lateral sclerosis 1 (ALS1)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

140 interactions

InteractorPartnerSourcesPublicationsLink
DCTN1_HUMANHDAC6_HUMANIntAct, MINT12024216 32814053 details
DCTN1_HUMANZ512B_HUMANBioGRID, MINT15231748 details
DCTN1_HUMANPGAM1_HUMANHPRD, IntAct16169070 details
DCTN1_HUMANCLIP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12789661 16362039 17828275 17828277 26638075 34079125 details
DCTN1_HUMANRAB6A_HUMANBioGRID, HPRD, MINT12401177 16473624 16902405 details
DCTN1_HUMANMAGA6_HUMANIntAct17353931 32814053 details
DCTN1_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
DCTN1_HUMANTAU_HUMANBioGRID, IntAct, MINT, UniProt17932487 26269332 26638075 32814053 34079125 details
DCTN1_HUMANBBS1_HUMANBioGRID, IntAct18000879 32814053 details
DCTN1_HUMANBBS4_HUMANBioGRID, IntAct, UniProt15107855 18000879 details
DCTN1_HUMANMTEF1_HUMANBioGRID, IntAct20195357 details
DCTN1_HUMANSTAT1_HUMANBioGRID, IntAct20936779 details
DCTN1_HUMANAKT1_HUMANBioGRID, MINT21900206 details
DCTN1_HUMANCDC37_HUMANBioGRID, MINT21900206 details
DCTN1_HUMANK0408_HUMANBioGRID, MINT21900206 details
DCTN1_HUMANDC1I1_HUMANBioGRID, IntAct, MINT21900206 22956769 28718761 32814053 details
DCTN1_HUMANNEK2_HUMANBioGRID, MINT21900206 details
DCTN1_HUMANPFD1_HUMANBioGRID, MINT21900206 details
DCTN1_HUMANENOB_HUMANBioGRID, IntAct23414517 details
DCTN1_HUMANPRPK_HUMANBioGRID, IntAct23414517 details
DCTN1_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
DCTN1_HUMANMARE1_HUMANBioGRID, DIP, HPRD, IntAct12388762 17828277 24997520 26496610 26638075 27173435 34079125 unassigned1312 details
DCTN1_HUMANDCTN3_HUMANBioGRID, HPRD, IntAct26638075 27173435 28514442 32814053 9722614 unassigned1312 details
DCTN1_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
DCTN1_HUMANCRYAB_HUMANbhf-ucl26465331 details
DCTN1_HUMANTBA3C_HUMANDIP17563362 details
DCTN1_HUMANTBA3D_HUMANDIP17563362 details
DCTN1_HUMANATF3_HUMANIntAct32814053 details
DCTN1_HUMANBIRC5_HUMANIntAct32814053 details
DCTN1_HUMANAP2B1_HUMANIntAct32814053 details
DCTN1_HUMANDLX3_HUMANIntAct32814053 details
DCTN1_HUMANCASP3_HUMANHPRD, IntAct11425872 32814053 details
DCTN1_HUMANRN112_HUMANIntAct32814053 details
DCTN1_HUMANBRK1_HUMANIntAct32814053 details
DCTN1_HUMANRL40_HUMANIntAct32814053 details
DCTN1_HUMANTERF2_HUMANIntAct32814053 details
DCTN1_HUMANRO52_HUMANIntAct32814053 details
DCTN1_HUMANRPGR_HUMANHPRD, IntAct16043481 32814053 details
DCTN1_HUMANPRS6A_HUMANIntAct32814053 details
DCTN1_HUMANNVL_HUMANIntAct32814053 details
DCTN1_HUMANESRP1_HUMANIntAct32814053 details
DCTN1_HUMANTOLIP_HUMANIntAct32814053 details
DCTN1_HUMANUBS3A_HUMANIntAct32814053 details
DCTN1_HUMANUIMC1_HUMANIntAct32814053 details
DCTN1_HUMANLSM8_HUMANIntAct32814053 details
DCTN1_HUMANUBXN1_HUMANIntAct32814053 details
DCTN1_HUMANRABX5_HUMANIntAct32814053 details
DCTN1_HUMANKLH20_HUMANIntAct32814053 details
DCTN1_HUMANSPAG8_HUMANIntAct32814053 details
DCTN1_HUMANKBP_HUMANIntAct32814053 details
DCTN1_HUMANRYBP_HUMANIntAct32814053 details
DCTN1_HUMANWWP2_HUMANIntAct32814053 details
DCTN1_HUMANSC23A_HUMANHPRD, IntAct15580264 32814053 details
DCTN1_HUMANUBAC1_HUMANIntAct32814053 details
DCTN1_HUMANSTAM2_HUMANIntAct32814053 details
DCTN1_HUMANIQEC1_HUMANIntAct32814053 details
DCTN1_HUMANFEZ2_HUMANIntAct32814053 details
DCTN1_HUMANASML_HUMANIntAct32814053 details
DCTN1_HUMANCSN3_HUMANIntAct32814053 details
DCTN1_HUMANBAG6_HUMANIntAct32814053 details
DCTN1_HUMANAN13D_HUMANIntAct32814053 details
DCTN1_HUMANUBAC2_HUMANIntAct32814053 details
DCTN1_HUMANENKUR_HUMANIntAct32814053 details
DCTN1_HUMANRN168_HUMANBioGRID, IntAct22939629 32814053 details
DCTN1_HUMANRN183_HUMANIntAct32814053 details
DCTN1_HUMANTWST2_HUMANIntAct32814053 details
DCTN1_HUMANLDH6B_HUMANIntAct32814053 details
DCTN1_HUMANIFT20_HUMANIntAct32814053 details
DCTN1_HUMANMPND_HUMANIntAct32814053 details
DCTN1_HUMANLMBL3_HUMANIntAct32814053 details
DCTN1_HUMANWDR61_HUMANIntAct32814053 details
DCTN1_HUMANTMUB2_HUMANIntAct32814053 details
DCTN1_HUMANSMUF1_HUMANBioGRID, IntAct23184937 32814053 details
DCTN1_HUMANOTU7B_HUMANIntAct32814053 details
DCTN1_HUMANOTUB1_HUMANIntAct32814053 details
DCTN1_HUMANPCMD2_HUMANIntAct32814053 details
DCTN1_HUMANA4_HUMANIntAct32814053 details
DCTN1_HUMANHAP1_HUMANBioGRID9361024 9454836 details
DCTN1_HUMANDYST_HUMANBioGRID, HPRD14581450 details
DCTN1_HUMANKIF11_HUMANBioGRID, HPRD9235942 details
DCTN1_HUMANGRB2_HUMANBioGRID, HPRD8955163 details
DCTN1_HUMANFBXL5_HUMANBioGRID17532294 details
DCTN1_HUMANMED14_HUMANBioGRID15604093 details
DCTN1_HUMANDTBP1_HUMANBioGRID17043677 details
DCTN1_HUMANDCTN1_HUMANBioGRID, HPRD11056532 9235942 details
DCTN1_HUMANRBL2_HUMANBioGRID16600870 details
DCTN1_HUMANNOD2_HUMANBioGRID27812135 details
DCTN1_HUMANAPEX1_HUMANBioGRID, HPRD28986522 9361024 details
DCTN1_HUMANMP2K6_HUMANHPRD15375157 details
DCTN1_HUMANACTY_HUMANBioGRID, HPRD, IntAct12857853 26186194 26344197 26638075 28514442 details
DCTN1_HUMANCASP4_HUMANIntAct17353931 details
DCTN1_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
DCTN1_HUMANARF6_HUMANIntAct17353931 details
DCTN1_HUMANVHL_HUMANIntAct17353931 details
DCTN1_HUMANCIAO1_HUMANIntAct17353931 details
DCTN1_HUMANBICD1_HUMANHPRD, MINT17139249 details
DCTN1_HUMANNDC80_HUMANBioGRID, IntAct, MINT20664522 26638075 34079125 details
DCTN1_HUMANDC2L1_HUMANMINT21252941 details
DCTN1_HUMANKIF3A_HUMANMINT23386061 details
DCTN1_HUMANNUMA1_HUMANMINT23921553 details
DCTN1_HUMANDYHC1_HUMANBioGRID, IntAct14600259 22939629 22956769 26344197 26496610 26638075 34079125 details
DCTN1_HUMANARP10_HUMANBioGRID, IntAct26638075 27173435 28514442 34079125 unassigned1312 details
DCTN1_HUMANDCTN4_HUMANBioGRID, IntAct26344197 26638075 27173435 28514442 28718761 34079125 unassigned1312 details
DCTN1_HUMANACTZ_HUMANBioGRID, HPRD, IntAct26344197 26638075 27173435 28514442 34079125 7878030 unassigned1312 details
DCTN1_HUMANDCTN6_HUMANBioGRID, IntAct26638075 27173435 28514442 unassigned1312 details
DCTN1_HUMANDCTN2_HUMANBioGRID, IntAct22939629 22956769 26186194 26344197 26638075 27173435 28514442 34079125 unassigned1312 details
DCTN1_HUMANNIN_HUMANBioGRID, IntAct26638075 28718761 34079125 details
DCTN1_HUMANLIS1_HUMANBioGRID, HPRD, IntAct11056532 11889140 14584027 26638075 27173435 unassigned1312 details
DCTN1_HUMANDC1I2_HUMANBioGRID, HPRD, IntAct26344197 26638075 28718761 34079125 8522607 details
DCTN1_HUMANCAPZB_HUMANBioGRID, IntAct26344197 27173435 28514442 unassigned1312 details
DCTN1_HUMANCAZA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DCTN1_HUMANNINL_HUMANBioGRID, IntAct26485645 27173435 28718761 unassigned1312 details
DCTN1_HUMANKCC2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
DCTN1_HUMANAHI1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DCTN1_HUMANSNX6_HUMANDIP23524952 details
DCTN1_HUMANCASS4_HUMANIntAct31413325 details
DCTN1_HUMANCD2AP_HUMANIntAct31413325 details
DCTN1_HUMANTNIK_HUMANIntAct31413325 details
DCTN1_HUMANFXR1_HUMANMINT21653829 details
DCTN1_HUMANHXA1_HUMANMINT21653829 details
DCTN1_HUMANVIME_HUMANBioGRID, HPRD14600259 details
DCTN1_HUMANPLK1_HUMANBioGRID12852857 34079125 details
DCTN1_HUMANEPB41_HUMANBioGRID10189366 details
DCTN1_HUMANSPTB2_HUMANBioGRID8991093 details
DCTN1_HUMANDYL1_HUMANBioGRID11056532 details
DCTN1_HUMANBICD2_HUMANBioGRID, HPRD11483508 12447383 22956769 28718761 details
DCTN1_HUMANDC1L1_HUMANBioGRID22956769 28718761 34079125 details
DCTN1_HUMANDYLT1_HUMANBioGRID26638075 28718761 details
DCTN1_HUMANDCDC1_HUMANBioGRID22159412 details
DCTN1_HUMANMYO6_HUMANBioGRID26950368 details
DCTN1_HUMANDC1L2_HUMANBioGRID28718761 34079125 details
DCTN1_HUMANDLRB1_HUMANBioGRID28718761 details
DCTN1_HUMANDAPLE_HUMANBioGRID28718761 details
DCTN1_HUMANGRDN_HUMANBioGRID28718761 details
DCTN1_HUMANHOOK3_HUMANBioGRID28718761 details
DCTN1_HUMANSPHK2_HUMANBioGRID30250299 details
DCTN1_HUMANCASP2_HUMANHPRD11425872 details
DCTN1_HUMANCASP7_HUMANHPRD11425872 details
DCTN1_HUMANSPTN2_HUMANHPRD11461920 details
DCTN1_HUMANGSK3B_HUMANHPRD17139249 details