Entity Details

Primary name FMO3
Entity type gene
Source Source Link

Details

PrimaryID2328
RefseqGeneNG_012690
SymbolFMO3
Nameflavin containing dimethylaniline monoxygenase 3
Chromosome1
Location1q24.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-12-10
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFMO3_HUMAN

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0006805 xenobiotic metabolic process
GO:0016021 integral component of membrane
GO:0034899 trimethylamine monooxygenase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding

Diseases

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Disease IDSourceNameDescription
602079 OMIMTrimethylaminuria (TMAU)Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
FMO3SACM1LBioGRID, IntAct32296183 details
FMO3SGSM3BioGRID, IntAct32296183 details
FMO3CLEC10ABioGRID, IntAct32296183 details
FMO3CREB3BioGRID, IntAct25910212 31515488 details