Entity Details

Primary name CUX2
Entity type gene
Source Source Link

Details

PrimaryID23316
RefseqGeneNG_023039
SymbolCUX2
Namecut like homeobox 2
Chromosome12
Location12q24.11-q24.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-30
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCUX2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007614 short-term memory
GO:0010628 positive regulation of gene expression
GO:0043565 sequence-specific DNA binding
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050890 cognition
GO:0051965 positive regulation of synapse assembly
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0070062 extracellular exosome
GO:0071310 cellular response to organic substance
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000463 positive regulation of excitatory postsynaptic potential

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618141 OMIMDevelopmental and epileptic encephalopathy 67 (DEE67)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE67 is an autosomal dominant form characterized by onset of seizures in infancy. Later onset of seizures in childhood may occur in some patients. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CUX2CSNK2A1HPRD9446557 details
CUX2HNRNPCBioGRID, IntAct30021884 details
CUX2ERGIntAct20478527 details
CUX2ARIntAct20478527 details