Entity Details

Primary name FRZB
Entity type gene
Source Source Link

Details

PrimaryID2487
RefseqGeneNG_017197
SymbolFRZB
Namefrizzled related protein
Chromosome2
Location2q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSFRP3_HUMAN

GO terms

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GOName
GO:0001501 skeletal system development
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008285 negative regulation of cell population proliferation
GO:0010721 negative regulation of cell development
GO:0014033 neural crest cell differentiation
GO:0016020 membrane
GO:0017147 Wnt-protein binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0070367 negative regulation of hepatocyte differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis

Diseases

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Disease IDSourceNameDescription
165720 OMIMOsteoarthritis 1 (OS1)A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

9 interactions

InteractorPartnerSourcesPublicationsLink
FRZBBBS10BioGRID, MINT21900206 details
FRZBEHFBioGRID, MINT21900206 details
FRZBELF5BioGRID, MINT21900206 details
FRZBPNO1BioGRID, MINT21900206 details
FRZBPOLA2BioGRID, MINT21900206 details
FRZBRBX1BioGRID, MINT21900206 details
FRZBSMAD1BioGRID, MINT21900206 details
FRZBCYSRT1BioGRID, IntAct32296183 details
FRZBSMC3BioGRID, IntAct30021884 details