Entity Details

Primary name TMEM98
Entity type gene
Source Source Link

Details

PrimaryID26022
RefseqGeneNG_034264
SymbolTMEM98
Nametransmembrane protein 98
Chromosome17
Location17q11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTMM98_HUMAN

GO terms

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GOName
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0010955 negative regulation of protein processing
GO:0016021 integral component of membrane
GO:0031642 negative regulation of myelination
GO:0045063 T-helper 1 cell differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0070062 extracellular exosome
GO:1900181 negative regulation of protein localization to nucleus

Diseases

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Disease IDSourceNameDescription
615972 OMIMNanophthalmos 4 (NNO4)A rare disorder of eye development characterized by extreme hyperopia (farsightedness) and small functional eyes. The cornea and lens are normal in size and shape. Hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. The disease is caused by variants affecting the gene represented in this entry.

Interactions

11 interactions

InteractorPartnerSourcesPublicationsLink
TMEM98RABEPKBioGRID, MINT21900206 details
TMEM98TNNT1BioGRID, MINT21900206 details
TMEM98SGTABioGRID, IntAct32296183 details
TMEM98ATP1B3BioGRID, IntAct32296183 details
TMEM98SUSD3BioGRID, IntAct32296183 details
TMEM98MUC1BioGRID, IntAct32296183 details
TMEM98GOLM1BioGRID, IntAct32296183 details
TMEM98STOMBioGRID, IntAct32296183 details
TMEM98GJB1BioGRID, IntAct32296183 details
TMEM98HTR6BioGRID, MINT28298427 details
TMEM98HNRNPLBioGRID28611215 details