Entity Details

Primary name PTPN22
Entity type gene
Source Source Link

Details

PrimaryID26191
RefseqGeneNG_011432
SymbolPTPN22
Nameprotein tyrosine phosphatase non-receptor type 22
Chromosome1
Location1p13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPTN22_HUMAN

GO terms

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GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006914 autophagy
GO:0009898 cytoplasmic side of plasma membrane
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0030217 T cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032817 regulation of natural killer cell proliferation
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0045088 regulation of innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071225 cellular response to muramyl dipeptide
GO:0071663 positive regulation of granzyme B production
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903753 negative regulation of p38MAPK cascade
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
PTPN22ZAP70BioGRID, HPRD, IntAct16461343 details
PTPN22LCKBioGRID, HPRD, IntAct16461343 19167335 21719704 details
PTPN22CD247BioGRID, HPRD, IntAct16461343 details
PTPN22CDH2IntAct19167335 details
PTPN22ERBB2IntAct19167335 details
PTPN22PDGFRBIntAct19167335 details
PTPN22NTRK1IntAct19167335 details
PTPN22PDPK1IntAct19167335 details
PTPN22GHRIntAct19167335 details
PTPN22WASIntAct19167335 details
PTPN22GRB2BioGRID, HPRD, MINT11882361 details
PTPN22EGFRBioGRID, IntAct24658140 25402006 31980649 details
PTPN22SKAP2IntAct21719704 details
PTPN22PRKCDDIP, HPRD18056643 details
PTPN22PTPN22BioGRID, DIP10068674 18056643 27432908 details
PTPN22SRPK2BioGRID26167880 details
PTPN22CLK1BioGRID26167880 details
PTPN22CBLBioGRID, HPRD, MINT10068674 details
PTPN22PSTPIP1MINT25040622 details
PTPN22TRAF3IntAct23871208 details
PTPN22SPTA1BioGRID16461343 details
PTPN22ACTA1BioGRID16461343 details
PTPN22CSKBioGRID, HPRD27432908 27880917 9582365 details
PTPN22VCPBioGRID, IntAct16461343 details
PTPN22VAV1BioGRID, HPRD, IntAct16461343 details
PTPN22CD3EBioGRID, HPRD, IntAct16461343 details
PTPN22VIMBioGRID, IntAct30021884 details
PTPN22PSTPIP2BioGRID27432908 27880917 details
PTPN22TBC1D31BioGRID27880917 details
PTPN22KIF7BioGRID27880917 details
PTPN22LZTS2BioGRID27880917 details
PTPN22CEP131BioGRID27880917 details
PTPN22PIBF1BioGRID27880917 details
PTPN22KIAA0753BioGRID27880917 details
PTPN22MIB1BioGRID27880917 details
PTPN22MED4BioGRID27880917 details
PTPN22SSX2IPBioGRID27880917 details
PTPN22CCDC138BioGRID27880917 details
PTPN22MAD2L1BPBioGRID27432908 details
PTPN22NDUFB10BioGRID27432908 details
PTPN22PRKAR2ABioGRID27432908 details
PTPN22AKR7A2BioGRID27432908 details
PTPN22NDUFA9BioGRID27432908 details
PTPN22CALRBioGRID27432908 details
PTPN22CALUBioGRID27432908 details
PTPN22SLC25A19BioGRID27432908 details
PTPN22SDF4BioGRID27432908 details
PTPN22MAIP1BioGRID27432908 details
PTPN22RPS19BP1BioGRID27432908 details
PTPN22SFXN4BioGRID27432908 details
PTPN22EIF3EBioGRID27432908 details
PTPN22HSPB1BioGRID27432908 details
PTPN22RCN1BioGRID27432908 details
PTPN22ACAD8BioGRID27432908 details
PTPN22GLUD1BioGRID27432908 details
PTPN22HAX1BioGRID27432908 details
PTPN22SCO2BioGRID27432908 details