Entity Details

Primary name OPLAH
Entity type gene
Source Source Link

Details

PrimaryID26873
RefseqGeneNG_032671
SymbolOPLAH
Name5-oxoprolinase, ATP-hydrolysing
Chromosome8
Location8q24.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsOPLA_HUMAN

GO terms

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GOName
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity
GO:0042802 identical protein binding

Diseases

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Disease IDSourceNameDescription
260005 OMIM5-oxoprolinase deficiency (OPLAHD)A disorder characterized by calcium oxalate/carbonate urolithiasis, and excessive urinary 5-oxo-L-proline. Affected individuals have recurrent episodes of vomiting, diarrhea, and abdominal pain. The disease is caused by variants affecting the gene represented in this entry.

Interactions

8 interactions

InteractorPartnerSourcesPublicationsLink
OPLAHGKBioGRID, IntAct21988832 details
OPLAHPOU6F2BioGRID, IntAct32296183 details
OPLAHOPLAHBioGRID, IntAct32296183 details
OPLAHTPK1BioGRID, IntAct32296183 details
OPLAHZNF451BioGRID32296183 details
OPLAHHOXA1MINT21653829 details
OPLAHNUDCD1MINT29021621 details
OPLAHRECQL4BioGRID29229926 details