Entity Details

Primary name GLRA1
Entity type gene
Source Source Link

Details

PrimaryID2741
RefseqGeneNG_011764
SymbolGLRA1
Nameglycine receptor alpha 1
Chromosome5
Location5q33.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-02-23
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGLRA1_HUMAN

GO terms

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GOName
GO:0001508 action potential
GO:0001964 startle response
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0004888 transmembrane signaling receptor activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007340 acrosome reaction
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0016594 glycine binding
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0030977 taurine binding
GO:0034220 ion transmembrane transport
GO:0034707 chloride channel complex
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043200 response to amino acid
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0044305 calyx of Held
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0050884 neuromuscular process controlling posture
GO:0051970 negative regulation of transmission of nerve impulse
GO:0060012 synaptic transmission, glycinergic
GO:0060013 righting reflex
GO:0060077 inhibitory synapse
GO:0060080 inhibitory postsynaptic potential
GO:0071230 cellular response to amino acid stimulus
GO:0071294 cellular response to zinc ion
GO:0071361 cellular response to ethanol
GO:0097305 response to alcohol
GO:0098690 glycinergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099060 integral component of postsynaptic specialization membrane
GO:1902476 chloride transmembrane transport
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:2000344 positive regulation of acrosome reaction

Diseases

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Disease IDSourceNameDescription
149400 OMIMHyperekplexia 1 (HKPX1)A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GLRA1SORBS3BioGRID, IntAct32296183 details
GLRA1MAGED1BioGRID, IntAct32296183 details
GLRA1GLRA1DIP20023641 23994010 details