Entity Details

Primary name SLCO1B3
Entity type gene
Source Source Link

Details

PrimaryID28234
RefseqGeneNG_032071
SymbolSLCO1B3
Namesolute carrier organic anion transporter family member 1B3
Chromosome12
Location12p12.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-01
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSO1B3_HUMAN

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008514 organic anion transmembrane transporter activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0016323 basolateral plasma membrane
GO:0042167 heme catabolic process
GO:0043252 sodium-independent organic anion transport

Diseases

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Disease IDSourceNameDescription
237450 OMIMHyperbilirubinemia, Rotor type (HBLRR)An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SLCO1B3CCKBRBioGRID10320330 details
SLCO1B3BRCA2BioGRID27433848 details