Entity Details

Primary name CHD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14839
EntryNameCHD4_HUMAN
FullNameChromodomain-helicase-DNA-binding protein 4
TaxID9606
Evidenceevidence at protein level
Length1912
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCHD4

GO terms

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GOName
GO:0000785 chromatin
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0016581 NuRD complex
GO:0032991 protein-containing complex
GO:0042826 histone deacetylase binding
GO:0043044 ATP-dependent chromatin remodeling
GO:0070615 nucleosome-dependent ATPase activity
GO:0090575 RNA polymerase II transcription regulator complex
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR000953 Chromo/chromo shadow domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR009462 Domain of unknown function DUF1086DomainDomain
IPR009463 Domain of unknown function DUF1087DomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR012957 CHD, C-terminal 2DomainDomain
IPR012958 CHD, N-terminalDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR016197 Chromo-like domain superfamilyFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR023780 Chromo domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617159 OMIMSifrim-Hitz-Weiss syndrome (SIHIWES)An autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients. The disease is caused by variants affecting the gene represented in this entry.

Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
CHD4_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
CHD4_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct, MINT10220385 11102443 12920132 20585571 20693977 21258344 21670149 22075476 22939629 23752268 24981860 25247294 26344197 26496610 26949739 27616479 28514442 28977666 9790534 9804427 9885572 details
CHD4_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
CHD4_HUMANRBBP4_HUMANBioGRID, IntAct, MINT21670149 22939629 24981860 26344197 27705803 28977666 9790534 9885572 details
CHD4_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
CHD4_HUMANRBBP7_HUMANBioGRID, IntAct22939629 25247294 26186194 28514442 28977666 9790534 details
CHD4_HUMANRNF8_HUMANBioGRID, MINT22531782 26546801 details
CHD4_HUMANSMCA4_HUMANBioGRID, IntAct11003653 14530259 16217013 28977666 details
CHD4_HUMANMB3L2_HUMANBioGRID15701600 details
CHD4_HUMANH31_HUMANBioGRID21278251 24576085 26527279 31970415 32251276 details
CHD4_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
CHD4_HUMANTWST1_HUMANBioGRID20714342 details
CHD4_HUMANCHD4_HUMANBioGRID21670149 22575888 28977666 details
CHD4_HUMANUBC9_HUMANBioGRID15561718 details
CHD4_HUMANH31T_HUMANBioGRID20850016 22749909 25247294 details
CHD4_HUMANATM_HUMANBioGRID21219611 details
CHD4_HUMANEP300_HUMANBioGRID, HPRD15189737 26546801 30110629 details
CHD4_HUMANSIR6_HUMANBioGRID24169447 31970415 details
CHD4_HUMANPARP1_HUMANBioGRID26546801 26565020 28977666 details
CHD4_HUMANTRI27_HUMANBioGRID, HPRD14530259 details
CHD4_HUMANADNP_HUMANBioGRID24981860 28977666 29795351 32533114 details
CHD4_HUMANH4_HUMANBioGRID28977666 30804502 32251276 details
CHD4_HUMANPCNT_HUMANBioGRID17626165 details
CHD4_HUMANH2A1B_HUMANBioGRID32251276 details
CHD4_HUMANPPIP1_HUMANBioGRID29907651 details
CHD4_HUMANPTEN_HUMANBioGRID31685992 details
CHD4_HUMANH2B1B_HUMANBioGRID32251276 details
CHD4_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
CHD4_HUMANRORG_HUMANHPRD15144897 details
CHD4_HUMANTAF9_HUMANIntAct20195357 details
CHD4_HUMANMTA2_HUMANBioGRID, IntAct, MINT12920132 19703393 20693977 21670149 22939629 24981860 25247294 26344197 28977666 9790534 details
CHD4_HUMANNR4A1_HUMANBioGRID, IntAct19321449 20195357 details
CHD4_HUMANHDAC2_HUMANBioGRID, IntAct, MINT10545197 11003653 12493763 21258344 21670149 22939629 23752268 24981860 26344197 26949739 28977666 30737378 9790534 9804427 9885572 details
CHD4_HUMANMTA3_HUMANBioGRID, IntAct21258344 22075476 24981860 26028330 26344197 28977666 details
CHD4_HUMANCBX5_HUMANBioGRID, IntAct15882967 24981860 27705803 28977666 details
CHD4_HUMANMBD3_HUMANBioGRID, IntAct, MINT12354758 21670149 22939629 24981860 25123934 25247294 28977666 details
CHD4_HUMANMTA1_HUMANBioGRID, IntAct12920132 21670149 24440720 24981860 26028330 26344197 28977666 9885572 details
CHD4_HUMANEHMT2_HUMANBioGRID, IntAct26028330 28486105 details
CHD4_HUMANPKCB1_HUMANBioGRID, IntAct26496610 26655721 28977666 31753913 details
CHD4_HUMANCHD3_HUMANBioGRID, IntAct22939629 24981860 28977666 9885572 details
CHD4_HUMANIKZF3_HUMANBioGRID12015313 30760870 details
CHD4_HUMANIKZF1_HUMANBioGRID, IntAct11003653 12015313 28514442 30760870 details
CHD4_HUMANPML_HUMANBioGRID18644863 details
CHD4_HUMANNAB1_HUMANBioGRID16574654 details
CHD4_HUMANMCRS1_HUMANBioGRID16186106 details
CHD4_HUMANZN827_HUMANBioGRID, DIP25150861 details
CHD4_HUMANSRRM1_HUMANBioGRID16159877 28977666 details
CHD4_HUMANSMCE1_HUMANBioGRID11003653 28977666 details
CHD4_HUMANSAP30_HUMANBioGRID24981860 9790534 details
CHD4_HUMANATR_HUMANBioGRID, HPRD10545197 details
CHD4_HUMANSIN3A_HUMANBioGRID24981860 9790534 details
CHD4_HUMANIKZF4_HUMANBioGRID, HPRD12015313 details
CHD4_HUMANH33_HUMANBioGRID17403666 details
CHD4_HUMANNAB2_HUMANBioGRID16574654 details
CHD4_HUMANSMRC1_HUMANBioGRID11003653 16217013 22939629 28977666 details
CHD4_HUMANBRD4_HUMANBioGRID21555454 31239290 32416067 details
CHD4_HUMANHNRPC_HUMANBioGRID16217013 28977666 details
CHD4_HUMANIKZF2_HUMANBioGRID12015313 details
CHD4_HUMANBC11B_HUMANBioGRID16091750 28977666 details
CHD4_HUMANCHD5_HUMANBioGRID21555454 25247294 details
CHD4_HUMANBC11A_HUMANBioGRID16091750 24981860 28977666 details
CHD4_HUMANBAF_HUMANBioGRID19759913 details
CHD4_HUMANMCPH1_HUMANBioGRID22219182 details
CHD4_HUMANUBS3B_HUMANBioGRID9790534 details
CHD4_HUMANNR2C1_HUMANBioGRID21670149 details
CHD4_HUMANSNAI1_HUMANBioGRID23011797 details
CHD4_HUMANDNM3B_HUMANBioGRID23708667 details
CHD4_HUMANPHF6_HUMANBioGRID22720776 details
CHD4_HUMANZFHX4_HUMANBioGRID24440720 28977666 details
CHD4_HUMANSMRCD_HUMANBioGRID21549307 details
CHD4_HUMANEZH2_HUMANBioGRID24981860 26344197 28068325 28486105 details
CHD4_HUMANDNMT1_HUMANBioGRID21670149 23708667 details
CHD4_HUMANH2AZ_HUMANBioGRID28242625 28298436 details
CHD4_HUMANBRD1_HUMANBioGRID27142060 28977666 details
CHD4_HUMANNR2C2_HUMANBioGRID21670149 30463901 details
CHD4_HUMANOGG1_HUMANBioGRID28486105 details
CHD4_HUMANTCF19_HUMANBioGRID29042441 details
CHD4_HUMANKDM1A_HUMANBioGRID21670149 details
CHD4_HUMANPHIP_HUMANBioGRID29089422 details
CHD4_HUMANEMD_HUMANBioGRID17620012 details
CHD4_HUMANDPOD3_HUMANBioGRID21670149 details
CHD4_HUMANPARK7_HUMANBioGRID20127688 details
CHD4_HUMANUBP43_HUMANBioGRID30135474 details
CHD4_HUMANSOX2_HUMANBioGRID21532573 details
CHD4_HUMANSNAI2_HUMANBioGRID23011797 details
CHD4_HUMANUBP11_HUMANBioGRID31504778 details
CHD4_HUMANNACC2_HUMANBioGRID22926524 details
CHD4_HUMANPHF5A_HUMANBioGRID32228507 details