Entity Details

Primary name RAPGEF1
Entity type gene
Source Source Link

Details

PrimaryID2889
RefseqGeneNG_050622
SymbolRAPGEF1
NameRap guanine nucleotide exchange factor 1
Chromosome9
Location9q34.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsRPGF1_HUMAN

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001568 blood vessel development
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0010976 positive regulation of neuron projection development
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030670 phagocytic vesicle membrane
GO:0032486 Rap protein signal transduction
GO:0032991 protein-containing complex
GO:0038180 nerve growth factor signaling pathway
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0046328 regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051898 negative regulation of protein kinase B signaling
GO:0061028 establishment of endothelial barrier
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090630 activation of GTPase activity
GO:0098609 cell-cell adhesion
GO:1901888 regulation of cell junction assembly
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000178 negative regulation of neural precursor cell proliferation

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
RAPGEF1CRKBioGRID, DIP, HPRD, IntAct, MINT10464310 11870224 12054111 17474147 17515907 18835194 19001122 19380743 31980649 7512734 7531694 8621483 8943292 9564038 details
RAPGEF1GRB2BioGRID, HPRD, IntAct, MINT20936779 7512734 8621483 8943292 details
RAPGEF1ABL1BioGRID, IntAct, MINT16443220 17474147 details
RAPGEF1SRCIntAct17474147 details
RAPGEF1FYNIntAct17474147 details
RAPGEF1NCK1IntAct17474147 details
RAPGEF1PIK3R1IntAct17474147 details
RAPGEF1CRKLBioGRID, HPRD, IntAct, MINT10608804 10753869 10907644 11167825 11466412 16443220 18835194 26496610 30480076 8621483 8978305 9129019 9311917 9344843 9374471 9820532 details
RAPGEF1RPS15BioGRID, IntAct21988832 details
RAPGEF1SLC20A1BioGRID, IntAct21988832 details
RAPGEF1MBIPBioGRID, IntAct21988832 details
RAPGEF1ATXN1BioGRID, IntAct23275563 details
RAPGEF1EGFRBioGRID, IntAct24658140 25402006 31980649 details
RAPGEF1RAP1ABioGRID, DIP22081014 9266971 details
RAPGEF1BCAR1BioGRID, HPRD9748234 details
RAPGEF1HCKBioGRID, HPRD10318861 12734187 14551197 details
RAPGEF1RAP2BBioGRID9266971 details
RAPGEF1CTLA4MINT24396067 details
RAPGEF1NEDD9BioGRID, HPRD9497377 9498705 details
RAPGEF1SHC1BioGRID, HPRD9344843 details
RAPGEF1CBLBioGRID10608804 18835194 details
RAPGEF1HRASBioGRID, HPRD10514505 30639242 details
RAPGEF1RRAS2HPRD12384139 details
RAPGEF1RAP1BHPRD8524240 details
RAPGEF1RHOQHPRD11309621 details
RAPGEF1SPATS2LBioGRID, IntAct26496610 details
RAPGEF1MOV10BioGRID22658674 details
RAPGEF1NXF1BioGRID22658674 details
RAPGEF1VIRMABioGRID29507755 details
RAPGEF1DDX58BioGRID32513696 details