Entity Details

Primary name GRM7
Entity type gene
Source Source Link

Details

PrimaryID2917
RefseqGeneNG_029781
SymbolGRM7
Nameglutamate metabotropic receptor 7
Chromosome3
Location3p26.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGRM7_HUMAN

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001642 group III metabotropic glutamate receptor activity
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007605 sensory perception of sound
GO:0008066 glutamate receptor activity
GO:0010855 adenylate cyclase inhibitor activity
GO:0014050 negative regulation of glutamate secretion
GO:0016021 integral component of membrane
GO:0016595 glutamate binding
GO:0030165 PDZ domain binding
GO:0030424 axon
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
GO:0048786 presynaptic active zone
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0070905 serine binding

Diseases

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Disease IDSourceNameDescription
618922 OMIMNeurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities (NEDSHBA)An autosomal recessive neurodevelopmental disorder characterized by global developmental delay, hypotonia, severe to profound intellectual disability, early-onset epilepsy, and microcephaly. Neuroimaging shows cerebral atrophy, thin corpus callosum and hypomyelination in a majority of cases. Death in childhood may occur. The disease is caused by variants affecting the gene represented in this entry.