Entity Details

Primary name GSS
Entity type gene
Source Source Link

Details

PrimaryID2937
RefseqGeneNG_008848
SymbolGSS
Nameglutathione synthetase
Chromosome20
Location20q11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1996-06-18
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGSHB_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006520 cellular amino acid metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007399 nervous system development
GO:0007568 aging
GO:0009410 response to xenobiotic stimulus
GO:0016594 glycine binding
GO:0031667 response to nutrient levels
GO:0034612 response to tumor necrosis factor
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043200 response to amino acid
GO:0043295 glutathione binding
GO:0046686 response to cadmium ion
GO:0070062 extracellular exosome

Diseases

Show/Hide Table
Disease IDSourceNameDescription
231900 OMIMGlutathione synthetase deficiency of erythrocytes (GLUSYNDE)Mild form causing hemolytic anemia. The disease is caused by variants affecting the gene represented in this entry.
266130 OMIMGlutathione synthetase deficiency (GSS deficiency)Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. The disease is caused by variants affecting the gene represented in this entry.