Entity Details

Primary name HLA-A
Entity type gene
Source Source Link

Details

PrimaryID3105
RefseqGeneNG_029217
SymbolHLA-A
Namemajor histocompatibility complex, class I, A
Chromosome6
Location6p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-10-04
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHLAA_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001913 T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002726 positive regulation of T cell cytokine production
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0016567 protein ubiquitination
GO:0019731 antibacterial humoral response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0062061 TAP complex binding
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2000568 positive regulation of memory T cell activation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Diseases

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Disease IDSourceNameDescription
126200 OMIMMultiple sclerosis (MS)A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
222100 OMIMDiabetes mellitus, insulin-dependent (IDDM)A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Interactions

218 interactions

InteractorPartnerSourcesPublicationsLink
HLA-AB2MBioGRID, HPRD, IntAct, MINT11502003 1448153 20831383 20844028 24163410 26439010 27649529 8805302 93026 details
HLA-ASTAT3BioGRID, IntAct21988832 details
HLA-AZDHHC17BioGRID, IntAct24705354 details
HLA-AKIR3DL2BioGRID, HPRD, IntAct24018270 8617928 8760804 details
HLA-AKIR2DS4IntAct24018270 details
HLA-ACCR9BioGRID, MINT28298427 details
HLA-ABUD31BioGRID, MINT28298427 details
HLA-AMEP1BUniProt27180358 details
HLA-ACD8ABioGRID, HPRD10809759 9177355 details
HLA-AMAGEA4BioGRID, HPRD11502003 21815906 details
HLA-AMAGEA1BioGRID, HPRD8647853 details
HLA-ABCAP31BioGRID, HPRD11163199 17056546 19342655 34079125 details
HLA-ACALRBioGRID15383281 details
HLA-AMEOX2BioGRID24722188 details
HLA-AGPR35BioGRID28298427 details
HLA-ALTB4R2BioGRID28298427 details
HLA-AHLA-CBioGRID, IntAct17353931 26186194 28514442 details
HLA-AHYOU1IntAct17353931 details
HLA-AHLA-AHPRD, IntAct12853576 17353931 8617928 8760804 9531263 details
HLA-AMICOS13IntAct17353931 details
HLA-AHLA-BBioGRID, IntAct17353931 26186194 28514442 details
HLA-ASMC2IntAct17353931 26439010 details
HLA-AHLA-GBioGRID, IntAct17353931 28514442 details
HLA-ASSR4IntAct17353931 details
HLA-AATP2A3IntAct17353931 details
HLA-AUGGT2IntAct17353931 details
HLA-AEFHD1IntAct17353931 details
HLA-APDIA3HPRD, MINT17467700 9545232 details
HLA-ATAPBPLIntAct24163410 26439010 details
HLA-ATAPBPBioGRID, HPRD, IntAct11884415 24163410 26439010 8769474 details
HLA-AKIR3DS1IntAct27649529 details
HLA-AIL12RB2IntAct28514442 details
HLA-ACANXBioGRID, HPRD, IntAct17467700 29568061 details
HLA-APRKAR1ABioGRID, HPRD, IntAct31980649 6333425 details
HLA-ADERL1BioGRID, HPRD15215855 21245296 34079125 details
HLA-ATAP1BioGRID11884415 17055437 details
HLA-ACOPB1BioGRID11884415 details
HLA-ACOPG1BioGRID11884415 details
HLA-ASYVN1BioGRID21245296 details
HLA-AUBE2J1BioGRID21245296 details
HLA-APSMD2BioGRID21245296 details
HLA-ATRAM1BioGRID19121997 details
HLA-ASEC61A1BioGRID14644099 details
HLA-ALMAN1BioGRID19342655 34079125 details
HLA-ATAP2BioGRID8805302 details
HLA-AATMBioGRID20064447 details
HLA-AGNASBioGRID9914489 details
HLA-ABAG6BioGRID21636303 details
HLA-AVCPBioGRID20702414 details
HLA-ATMEM129BioGRID24807418 25030448 details
HLA-AHERC2BioGRID25476789 details
HLA-AATG5BioGRID33024031 details
HLA-AUBBHPRD14722266 details
HLA-ADEKHPRD9684994 details
HLA-AAPLP2HPRD19184004 details
HLA-AERBB2HPRD10593938 details
HLA-APRKCAHPRD2941417 details
HLA-ASRCHPRD6304688 6333425 details
HLA-AUGGT1BioGRID, IntAct17353931 details
HLA-ACD9MINT23289620 details
HLA-AMMEIntAct, MINT23289620 28514442 details
HLA-AEGFRBioGRID, IntAct24189400 24797263 details
HLA-AERBB3BioGRID, IntAct24189400 26186194 28514442 details
HLA-AILKBioGRID, IntAct25852190 details
HLA-ATCTN3IntAct26638075 details
HLA-ATMEM17BioGRID, IntAct26638075 details
HLA-ASCLT1BioGRID, IntAct26638075 details
HLA-AHSCBBioGRID, IntAct28380382 details
HLA-ALILRB1BioGRID, HPRD, IntAct12897781 details
HLA-AMIS18AIntAct26439010 details
HLA-AETFBIntAct26439010 details
HLA-AHSP90AA1IntAct26439010 details
HLA-AMOV10IntAct26439010 details
HLA-AHLA-FIntAct20483783 26439010 details
HLA-AINSIntAct24018270 details
HLA-APLEKHA7IntAct28877994 details
HLA-ASLC39A5BioGRID, IntAct28514442 details
HLA-AHLA-DPA1BioGRID, IntAct26186194 28514442 details
HLA-ADLK2IntAct28514442 details
HLA-ATMEM30BIntAct28514442 details
HLA-AIL13RA2IntAct28514442 details
HLA-AGABREBioGRID, IntAct26186194 28514442 details
HLA-AHLA-EBioGRID, IntAct26186194 28514442 details
HLA-APRG2BioGRID, IntAct26186194 28514442 details
HLA-ATMPRSS11BBioGRID, IntAct28514442 details
HLA-ATMPRSS3BioGRID, IntAct28514442 details
HLA-ALRRC4CIntAct28514442 details
HLA-ATDGF1IntAct28514442 details
HLA-APCDHB11IntAct28514442 details
HLA-AFCGRTIntAct28514442 details
HLA-AHS2ST1BioGRID, IntAct26186194 28514442 details
HLA-AP2RX5IntAct28514442 details
HLA-AGLB1IntAct28514442 details
HLA-ACD1BBioGRID, IntAct26186194 28514442 details
HLA-AIL27RAIntAct28514442 details
HLA-APTCH1BioGRID, IntAct26186194 28514442 details
HLA-ASCARA3BioGRID, IntAct26186194 28514442 details
HLA-AIL20RBBioGRID, IntAct26186194 28514442 details
HLA-AGABRG2IntAct28514442 details
HLA-AZACNBioGRID, IntAct26186194 28514442 details
HLA-ANAXDBioGRID, IntAct28514442 details
HLA-ATCTN2BioGRID, IntAct28514442 details
HLA-AADAM33BioGRID, IntAct28514442 details
HLA-ATOR1AIntAct28514442 details
HLA-AFUT3IntAct28514442 details
HLA-ANRN1IntAct28514442 details
HLA-AADAM2IntAct28514442 details
HLA-AITM2BBioGRID, IntAct26186194 28514442 details
HLA-ASCNN1DIntAct28514442 details
HLA-AGABRA6IntAct28514442 details
HLA-AENTPD7IntAct28514442 details
HLA-ALILRB4IntAct28514442 details
HLA-ACD300EIntAct28514442 details
HLA-AOPCMLIntAct28514442 details
HLA-ACD3EBioGRID, IntAct26186194 28514442 details
HLA-AAPOMIntAct28514442 details
HLA-ABET1BioGRID, IntAct29568061 details
HLA-ALAMP1BioGRID, IntAct29568061 34079125 details
HLA-ATGOLN2BioGRID, IntAct29568061 details
HLA-APTGS2BioGRID, IntAct30021884 details
HLA-AVAV1BioGRID, IntAct31980649 details
HLA-APXNBioGRID, IntAct31980649 details
HLA-ASHOC2BioGRID, IntAct31980649 details
HLA-APAK1BioGRID, IntAct31980649 details
HLA-AUBCBioGRID16196087 details
HLA-AMMS19BioGRID22678362 details
HLA-ACUL7BioGRID24711643 details
HLA-ACCDC8BioGRID24711643 details
HLA-AIRAK1BioGRID25852190 details
HLA-AHLA-DQA1BioGRID26186194 details
HLA-AHLA-DRB5BioGRID26186194 details
HLA-AATP1B4BioGRID26186194 details
HLA-ARPS6KB2BioGRID25324306 details
HLA-ANTRK1BioGRID25921289 details
HLA-AIFI16BioGRID25693804 details
HLA-AATXN3BioGRID26496610 details
HLA-APCDHB15BioGRID26496610 details
HLA-APTPN5BioGRID27880917 details
HLA-APTPROBioGRID27432908 details
HLA-ADLSTBioGRID29128334 details
HLA-ASDHABioGRID29128334 details
HLA-AEGLN3BioGRID26972000 details
HLA-AMAPK6BioGRID26972000 details
HLA-AADSS2BioGRID27684187 details
HLA-ABMPR1ABioGRID27684187 details
HLA-ACDK9BioGRID27684187 details
HLA-ATGFB1BioGRID27684187 details
HLA-ARNF4BioGRID29180619 details
HLA-AGPC1BioGRID27576135 details
HLA-AHRASBioGRID30194290 30639242 details
HLA-ANRASBioGRID30194290 30639242 details
HLA-AVIRMABioGRID29507755 details
HLA-ATMEM41BBioGRID30352685 details
HLA-AKRASBioGRID30194290 34079125 details
HLA-AHADHBBioGRID31536960 details
HLA-ACYB5R3BioGRID31536960 details
HLA-AOASLBioGRID30833792 details
HLA-AITFG1BioGRID25437307 details
HLA-ABIRC3BioGRID30948266 details
HLA-ALMBR1LBioGRID31073040 details
HLA-AHIF1ANBioGRID31299612 details
HLA-AFANCD2BioGRID31180492 details
HLA-AEMC1BioGRID27342126 details
HLA-AEMC2BioGRID27342126 details
HLA-AEMC4BioGRID27342126 details
HLA-AMMGT1BioGRID27342126 details
HLA-AIMMP2LBioGRID31617661 details
HLA-AKIF14BioGRID31586073 details
HLA-ANPC1BioGRID33144569 details
HLA-ARBM39BioGRID28302793 details
HLA-AFAM20CBioGRID32149426 details
HLA-ADNAJC25BioGRID33957083 details
HLA-ADNAJC5BioGRID33957083 details
HLA-ARNF128BioGRID32614325 details
HLA-APMAIP1BioGRID32913203 details
HLA-ABAG5BioGRID32850835 details
HLA-AANKFY1BioGRID34079125 details
HLA-AARF6BioGRID34079125 details
HLA-AATP2A1BioGRID34079125 details
HLA-AB3GAT1BioGRID34079125 details
HLA-AC11orf52BioGRID34079125 details
HLA-ACALR3BioGRID34079125 details
HLA-ACAV1BioGRID34079125 details
HLA-ACXADRBioGRID34079125 details
HLA-ADIRAS3BioGRID34079125 details
HLA-AEBAG9BioGRID34079125 details
HLA-AELOVL5BioGRID34079125 details
HLA-AERGIC1BioGRID34079125 details
HLA-AEZRBioGRID34079125 details
HLA-AGJA1BioGRID34079125 details
HLA-AGJD3BioGRID34079125 details
HLA-AHSD17B11BioGRID34079125 details
HLA-AHSD3B7BioGRID34079125 details
HLA-ALAMP2BioGRID34079125 details
HLA-ALAMP3BioGRID34079125 details
HLA-ALAMTOR1BioGRID34079125 details
HLA-ALYNBioGRID34079125 details
HLA-AMARCKSBioGRID34079125 details
HLA-AMETTL7ABioGRID34079125 details
HLA-AOCLNBioGRID34079125 details
HLA-APANX1BioGRID34079125 details
HLA-ARAB11ABioGRID34079125 details
HLA-ARAB2ABioGRID34079125 details
HLA-ARAB35BioGRID34079125 details
HLA-ARAB4ABioGRID34079125 details
HLA-ARAB5ABioGRID34079125 details
HLA-ARAB5CBioGRID34079125 details
HLA-ARAB9ABioGRID34079125 details
HLA-ARHOBBioGRID34079125 details
HLA-ARPN1BioGRID34079125 details
HLA-ARPN2BioGRID34079125 details
HLA-ASEC62BioGRID34079125 details
HLA-ASTX4BioGRID34079125 details
HLA-ASTX6BioGRID34079125 details
HLA-ASTX7BioGRID34079125 details
HLA-AZFPL1BioGRID34079125 details
HLA-AMEX3CBioGRID28808060 details
HLA-AMEX3BBioGRID29496759 details