Entity Details

Primary name HTR1A
Entity type gene
Source Source Link

Details

PrimaryID3350
RefseqGeneNG_032816
SymbolHTR1A
Name5-hydroxytryptamine receptor 1A
Chromosome5
Location5q12.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-10-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDs5HT1A_HUMAN

GO terms

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GOName
GO:0001662 behavioral fear response
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008284 positive regulation of cell population proliferation
GO:0014062 regulation of serotonin secretion
GO:0019229 regulation of vasoconstriction
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0035640 exploration behavior
GO:0042053 regulation of dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0045202 synapse
GO:0046883 regulation of hormone secretion
GO:0050795 regulation of behavior
GO:0051378 serotonin binding
GO:0090722 receptor-receptor interaction

Diseases

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Disease IDSourceNameDescription
614674 OMIMPeriodic fever, menstrual cycle-dependent (PFMC)A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. The disease is caused by variants affecting the gene represented in this entry.