Entity Details

Primary name CDK10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15131
EntryNameCDK10_HUMAN
FullNameCyclin-dependent kinase 10
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCDK10

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007089 traversing start control point of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030030 cell projection organization
GO:0032956 regulation of actin cytoskeleton organization
GO:0036064 ciliary basal body
GO:0043410 positive regulation of MAPK cascade
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902018 negative regulation of cilium assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044093 Cyclin-dependent kinase 10, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
617694 OMIMAl Kaissi syndrome (ALKAS)An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay. The disease is caused by variants affecting the gene represented in this entry.