Entity Details

Primary name APOC3
Entity type gene
Source Source Link

Details

PrimaryID345
RefseqGeneNG_008949
SymbolAPOC3
Nameapolipoprotein C3
Chromosome11
Location11q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsAPOC3_HUMAN

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0006641 triglyceride metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0010987 negative regulation of high-density lipoprotein particle clearance
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0015485 cholesterol binding
GO:0019433 triglyceride catabolic process
GO:0030234 enzyme regulator activity
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0042157 lipoprotein metabolic process
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045833 negative regulation of lipid metabolic process
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050995 negative regulation of lipid catabolic process
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0055102 lipase inhibitor activity
GO:0060621 negative regulation of cholesterol import
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070328 triglyceride homeostasis
GO:0070653 high-density lipoprotein particle receptor binding

Diseases

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Disease IDSourceNameDescription
614028 OMIMHyperalphalipoproteinemia 2 (HALP2)A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. The disease is caused by variants affecting the gene represented in this entry.

Interactions

19 interactions