Entity Details

Primary name MCIDAS
Entity type gene
Source Source Link

Details

PrimaryID345643
RefseqGeneNG_051620
SymbolMCIDAS
Namemulticiliate differentiation and DNA synthesis associated cell cycle protein
Chromosome5
Location5q11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2003-03-28
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMCIN_HUMAN

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008156 negative regulation of DNA replication
GO:0016604 nuclear body
GO:0042802 identical protein binding
GO:0044458 motile cilium assembly
GO:0045786 negative regulation of cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060271 cilium assembly
GO:0098534 centriole assembly
GO:1902017 regulation of cilium assembly
GO:1903251 multi-ciliated epithelial cell differentiation

Diseases

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Disease IDSourceNameDescription
618695 OMIMCiliary dyskinesia, primary, 42 (CILD42)A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Other more variable features may include infertility and mild hydrocephalus. Patients with this form of the disorder do not have situs abnormalities. CILD42 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
MCIDASMCIDASUniProt21543332 details
MCIDASBYSLBioGRID, IntAct32296183 details
MCIDASZBTB24BioGRID, IntAct32296183 details
MCIDASTCEANCBioGRID, IntAct32296183 details
MCIDASGMNNBioGRID, IntAct, UniProt21543332 28514442 details
MCIDASTFDP1BioGRID, IntAct27705803 details