Entity Details

Primary name ZFP57
Entity type gene
Source Source Link

Details

PrimaryID346171
RefseqGeneNG_013045
SymbolZFP57
NameZFP57 zinc finger protein
Chromosome6
Location6p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2003-03-28
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsZFP57_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0043045 DNA methylation involved in embryo development
GO:0046872 metal ion binding

Diseases

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Disease IDSourceNameDescription
601410 OMIMDiabetes mellitus, transient neonatal, 1 (TNDM1)An autosomal dominant form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first month of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

12 interactions

InteractorPartnerSourcesPublicationsLink
ZFP57DVL3BioGRID, IntAct32296183 details
ZFP57YOD1BioGRID, IntAct32296183 details
ZFP57POLR1CBioGRID, IntAct32296183 details
ZFP57MKRN3BioGRID, IntAct32296183 details
ZFP57KANK2BioGRID, IntAct32296183 details
ZFP57EMDBioGRID, IntAct32296183 details
ZFP57CIB3BioGRID, IntAct32296183 details
ZFP57MLH1BioGRID, IntAct32296183 details
ZFP57DNMT1BioGRID22055183 details
ZFP57DNMT3ABioGRID22055183 details
ZFP57DNMT3BBioGRID22055183 details
ZFP57TRIM28BioGRID22055183 details