Entity Details

Primary name LPL
Entity type gene
Source Source Link

Details

PrimaryID4023
RefseqGeneNG_008855
SymbolLPL
Namelipoprotein lipase
Chromosome8
Location8p21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1989-04-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLIPL_HUMAN

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0004465 lipoprotein lipase activity
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0008201 heparin binding
GO:0008970 phospholipase A1 activity
GO:0009409 response to cold
GO:0009617 response to bacterium
GO:0009749 response to glucose
GO:0009986 cell surface
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010886 positive regulation of cholesterol storage
GO:0010890 positive regulation of sequestering of triglyceride
GO:0016042 lipid catabolic process
GO:0016298 lipase activity
GO:0017129 triglyceride binding
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0031670 cellular response to nutrient
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034185 apolipoprotein binding
GO:0034361 very-low-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0042493 response to drug
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0043395 heparan sulfate proteoglycan binding
GO:0043495 protein-membrane adaptor activity
GO:0045600 positive regulation of fat cell differentiation
GO:0050729 positive regulation of inflammatory response
GO:0051004 regulation of lipoprotein lipase activity
GO:0052739 phosphatidylserine 1-acylhydrolase activity
GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0070328 triglyceride homeostasis
GO:0071398 cellular response to fatty acid
GO:0071813 lipoprotein particle binding
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

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Disease IDSourceNameDescription
238600 OMIMHyperlipoproteinemia 1 (HLPP1)An autosomal recessive metabolic disorder characterized by defective breakdown of dietary fats, impaired clearance of chylomicrons from plasma causing the plasma to have a milky appearance, and severe hypertriglyceridemia. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. The disease is caused by variants affecting the gene represented in this entry.
144250 OMIMHyperlipidemia, familial combined, 3 (FCHL3)A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. FCHL3 inheritance is autosomal dominant. Disease susceptibility is associated with variants affecting the gene represented in this entry.