Entity Details

Primary name PTN14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15678
EntryNamePTN14_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 14
TaxID9606
Evidenceevidence at protein level
Length1187
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN14

GO terms

Show/Hide Table
GOName
GO:0001946 lymphangiogenesis
GO:0003712 transcription coregulator activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0030971 receptor tyrosine kinase binding
GO:0046825 regulation of protein export from nucleus
GO:0071345 cellular response to cytokine stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000299 FERM domainDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14/21FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041782 PTPN14/21, FERM domain C-lobeDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613611 OMIMChoanal atresia and lymphedema (CATLPH)A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.

Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
PTN14_HUMANYAP1_HUMANBioGRID, DIP, IntAct, MINT22948661 24255178 24366813 25283809 25751139 25796446 27432908 27684187 28514442 28675297 32292505 details
PTN14_HUMANTRIP6_HUMANBioGRID, IntAct32296183 details
PTN14_HUMANAMOT_HUMANBioGRID22948661 27432908 32296183 34079125 details
PTN14_HUMANKIBRA_HUMANBioGRID, IntAct22948661 24366813 25023289 27432908 28514442 28675297 28720576 details
PTN14_HUMAN1433B_HUMANBioGRID, IntAct22948661 24255178 27432908 28514442 details
PTN14_HUMANLATS1_HUMANBioGRID, IntAct24255178 25023289 34079125 details
PTN14_HUMANDCLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANSI1L1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANMAST3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANGGYF1_HUMANIntActunassigned1312 details
PTN14_HUMANNF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANHDAC4_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANZN638_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANDEN4C_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANSYDE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANSRS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANMAGI1_HUMANBioGRID, IntAct27173435 28514442 unassigned1312 details
PTN14_HUMANTESK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANRTKN_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANINP5E_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANCING_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANLIMA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANPPM1H_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PTN14_HUMAN1433G_HUMANBioGRID, HPRD, IntAct15324660 27432908 28514442 details
PTN14_HUMANCTNB1_HUMANBioGRID, HPRD12808048 details
PTN14_HUMANCTNA1_HUMANBioGRID12808048 details
PTN14_HUMANZO1_HUMANBioGRID, HPRD12808048 details
PTN14_HUMANPLAK_HUMANBioGRID, HPRD12808048 details
PTN14_HUMANPTEN_HUMANBioGRID15717329 details
PTN14_HUMAN1433E_HUMANBioGRID17979178 22948661 details
PTN14_HUMANCUL2_HUMANBioGRID22948661 27432908 details
PTN14_HUMANPLK1_HUMANBioGRID22948661 27432908 details
PTN14_HUMANDDB1_HUMANBioGRID22948661 details
PTN14_HUMAN2AAA_HUMANBioGRID22948661 details
PTN14_HUMAN2ABA_HUMANBioGRID22948661 details
PTN14_HUMAN1433Z_HUMANBioGRID22948661 details
PTN14_HUMANWWC2_HUMANBioGRID22948661 27432908 28675297 details
PTN14_HUMANUBC_HUMANBioGRID22948661 details
PTN14_HUMANCSN4_HUMANBioGRID22948661 27432908 details
PTN14_HUMANSTK3_HUMANBioGRID22948661 27432908 details
PTN14_HUMANLLR1_HUMANBioGRID22948661 27432908 details
PTN14_HUMANWWP1_HUMANBioGRID22948661 27432908 31340145 details
PTN14_HUMANWWP2_HUMANBioGRID22948661 25071155 31048545 details
PTN14_HUMANKC1D_HUMANBioGRID22948661 details
PTN14_HUMANVHL_HUMANBioGRID22948661 details
PTN14_HUMANRC3H2_HUMANBioGRID30209976 details
PTN14_HUMANSMAG2_HUMANBioGRID29395067 details
PTN14_HUMANSOCS7_HUMANBioGRID32978373 details
PTN14_HUMANCTNA2_HUMANHPRD12808048 details