Entity Details

Primary name ACHA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15822
EntryNameACHA2_HUMAN
FullNameNeuronal acetylcholine receptor subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length529
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCHRNA2

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0015464 acetylcholine receptor activity
GO:0016021 integral component of membrane
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030594 neurotransmitter receptor activity
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
610353 OMIMEpilepsy, nocturnal frontal lobe, 4 (ENFL4)An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. The disease is caused by variants affecting the gene represented in this entry.
610353 OMIMEpilepsy, nocturnal frontal lobe, 4 (ENFL4)An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00184 NicotineDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00416 Metocurine iodideDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00483 Gallamine triethiodideDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00565 CisatracuriumDrugbanksmall molecule
DB00657 MecamylamineDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00728 RocuroniumDrugbanksmall molecule
DB00732 Atracurium besylateDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01135 DoxacuriumDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01226 MivacuriumDrugbanksmall molecule
DB01245 DecamethoniumDrugbanksmall molecule
DB01336 MetocurineDrugbanksmall molecule
DB01337 PancuroniumDrugbanksmall molecule
DB01338 PipecuroniumDrugbanksmall molecule
DB01339 VecuroniumDrugbanksmall molecule
DB05740 RPI-78MDrugbanksmall molecule
DB07720 EpibatidineDrugbanksmall molecule
DB08960 HexamethoniumDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ACHA2_HUMANACHB2_HUMANHPRD8906617 details
ACHA2_HUMANACHB4_HUMANHPRD8906617 details