Entity Details

Primary name ADIPO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15848
EntryNameADIPO_HUMAN
FullNameAdiponectin
TaxID9606
Evidenceevidence at protein level
Length244
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesADIPOQ

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006635 fatty acid beta-oxidation
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0009617 response to bacterium
GO:0009744 response to sucrose
GO:0009749 response to glucose
GO:0009967 positive regulation of signal transduction
GO:0009986 cell surface
GO:0010467 gene expression
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010739 positive regulation of protein kinase A signaling
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875 positive regulation of cholesterol efflux
GO:0010906 regulation of glucose metabolic process
GO:0014823 response to activity
GO:0019395 fatty acid oxidation
GO:0030336 negative regulation of cell migration
GO:0030853 negative regulation of granulocyte differentiation
GO:0031953 negative regulation of protein autophosphorylation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032757 positive regulation of interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0033034 positive regulation of myeloid cell apoptotic process
GO:0033691 sialic acid binding
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034383 low-density lipoprotein particle clearance
GO:0034612 response to tumor necrosis factor
GO:0035690 cellular response to drug
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 negative regulation of MAP kinase activity
GO:0045471 response to ethanol
GO:0045599 negative regulation of fat cell differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046326 positive regulation of glucose import
GO:0046888 negative regulation of hormone secretion
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050765 negative regulation of phagocytosis
GO:0050805 negative regulation of synaptic transmission
GO:0050873 brown fat cell differentiation
GO:0051384 response to glucocorticoid
GO:0062023 collagen-containing extracellular matrix
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070543 response to linoleic acid
GO:0070994 detection of oxidative stress
GO:0071320 cellular response to cAMP
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071872 cellular response to epinephrine stimulus
GO:0072659 protein localization to plasma membrane
GO:0090317 negative regulation of intracellular protein transport
GO:0110113 positive regulation of lipid transporter activity
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900121 negative regulation of receptor binding
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000467 positive regulation of glycogen (starch) synthase activity
GO:2000478 positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000534 positive regulation of renal albumin absorption
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000590 negative regulation of metanephric mesenchymal cell migration

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001073 C1q domainDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR028572 AdiponectinFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612556 OMIMAdiponectin deficiency (ADPND)A condition that results in very low concentrations of plasma adiponectin. The disease is caused by variants affecting the gene represented in this entry.
125853 OMIMDiabetes mellitus, non-insulin-dependent (NIDDM)A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
ADIPO_HUMANSGTA_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
ADIPO_HUMANKELL_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANTNF14_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANBIK_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCAMLG_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANB2L13_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANNEMP1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANFAS_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMS4A3_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMFSD6_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCYBC1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCPLX4_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANPEX12_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCNR2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANT179B_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANPVR_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANAMGO1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANGPR42_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANFKBP7_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANFCGR1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANSYAP1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANSIG12_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANBTNL9_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANF209A_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANGP152_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCOQ9_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANS35E3_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANFNDC9_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCLD9_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANDHB11_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMRM1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMFF_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANSYNE4_HUMANBioGRID, IntAct25416956 25910212 32296183 details
ADIPO_HUMANTMPS2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCLC2D_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANASGR2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCLC10_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANPKR2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANSGTB_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANTM237_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCC107_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANERP29_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANNACHO_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANSCN3B_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANKCNK5_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANINGR2_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANBSND_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANS22AN_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANMO2R1_HUMANBioGRID, IntAct32296183 details
ADIPO_HUMANBNI3L_HUMANBioGRID, IntAct25910212 details
ADIPO_HUMANKASH5_HUMANBioGRID, IntAct25416956 25910212 details
ADIPO_HUMANHD_HUMANIntAct32814053 details
ADIPO_HUMANADIPO_HUMANBioGRID12021245 19855092 details
ADIPO_HUMANMOT8_HUMANBioGRID32296183 details
ADIPO_HUMANC1T9A_HUMANIntAct19666007 details
ADIPO_HUMANC1T9B_HUMANIntAct19666007 details
ADIPO_HUMANPDGFB_HUMANBioGRID12070119 details
ADIPO_HUMANCAD13_HUMANHPRD15210937 details
ADIPO_HUMANPAQR2_HUMANHPRD12802337 details