Entity Details

Primary name NFE2L1
Entity type gene
Source Source Link

Details

PrimaryID4779
RefseqGene
SymbolNFE2L1
Namenuclear factor, erythroid 2 like 1
Chromosome17
Location17q21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNF2L1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0008289 lipid binding
GO:0009653 anatomical structure morphogenesis
GO:0015485 cholesterol binding
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0034599 cellular response to oxidative stress
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0042632 cholesterol homeostasis
GO:0045454 cell redox homeostasis
GO:0046982 protein heterodimerization activity
GO:0055088 lipid homeostasis
GO:0071397 cellular response to cholesterol
GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress
GO:1901329 regulation of odontoblast differentiation

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
NFE2L1CD6BioGRID, IntAct21988832 details
NFE2L1KEAP1BioGRID, IntAct16687406 21262351 21988832 29255090 30126895 details
NFE2L1TULP3BioGRID, IntAct23414517 details
NFE2L1MAFGBioGRID, HPIDb, HPRD, IntAct, UniProt20102225 23661758 31467278 8932385 9150357 9421508 details
NFE2L1CREBZFBioGRID, HPIDb, UniProt20102225 23661758 details
NFE2L1NFE2HPIDb20102225 details
NFE2L1ATF7HPIDb20102225 details
NFE2L1ATF4HPIDb, HPRD11025215 20102225 details
NFE2L1FOSHPIDb20102225 details
NFE2L1BATFHPIDb20102225 details
NFE2L1MAFBHPIDb20102225 details
NFE2L1NFE2L1BioGRID, HPIDb, UniProt20102225 23661758 details
NFE2L1PARVABioGRID, IntAct27107012 details
NFE2L1MAFFBioGRID, HPRD, IntAct, UniProt23661758 26186194 28514442 8932385 details
NFE2L1NFE2L3BioGRID, UniProt23661758 details
NFE2L1BACH2BioGRID, UniProt23661758 details
NFE2L1HCFC1BioGRID, IntAct20211142 29941490 details
NFE2L1JUNBioGRID, HPRD9872330 details
NFE2L1CAPN1BioGRID, HPRD12358155 details
NFE2L1GSK3BBioGRID23623971 details
NFE2L1FMR1IntAct31413325 details
NFE2L1CEP63IntAct31413325 details
NFE2L1FBXW7BioGRID21953459 23623971 details
NFE2L1BTRCBioGRID25900982 29941490 details
NFE2L1USP15BioGRID27416755 details
NFE2L1OGTBioGRID29941490 details
NFE2L1MAFKHPRD12805554 details
NFE2L1JUNBHPRD9872330 details
NFE2L1JUNDHPRD9872330 details
NFE2L1WDFY3BioGRID, IntAct26496610 details
NFE2L1BRD9BioGRID, IntAct26496610 details
NFE2L1RUSC2BioGRID, IntAct26496610 details
NFE2L1C8orf33BioGRID, IntAct26496610 details
NFE2L1FBXW11BioGRID25515538 details
NFE2L1PHF12BioGRID26841866 details
NFE2L1GATAD1BioGRID26841866 details
NFE2L1MYCBioGRID30415952 details
NFE2L1FBXO38BioGRID30804394 details
NFE2L1APEX1BioGRID28986522 details
NFE2L1HNRNPH1BioGRID26760575 details
NFE2L1DDX58BioGRID32513696 details