Entity Details

Primary name NOS3
Entity type gene
Source Source Link

Details

PrimaryID4846
RefseqGeneNG_011992
SymbolNOS3
Namenitric oxide synthase 3
Chromosome7
Location7q36.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsNOS3_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001974 blood vessel remodeling
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003785 actin monomer binding
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007005 mitochondrion organization
GO:0007263 nitric oxide mediated signal transduction
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell population proliferation
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010544 negative regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0012506 vesicle membrane
GO:0014740 negative regulation of muscle hyperplasia
GO:0014806 smooth muscle hyperplasia
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0019430 removal of superoxide radicals
GO:0020037 heme binding
GO:0030666 endocytic vesicle membrane
GO:0031284 positive regulation of guanylate cyclase activity
GO:0031644 regulation of nervous system process
GO:0032496 response to lipopolysaccharide
GO:0034405 response to fluid shear stress
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0042311 vasodilation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0045454 cell redox homeostasis
GO:0045747 positive regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0046146 tetrahydrobiopterin metabolic process
GO:0046870 cadmium ion binding
GO:0048873 homeostasis of number of cells within a tissue
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0070168 negative regulation of biomineral tissue development
GO:0097746 blood vessel diameter maintenance
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Diseases

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Interactions

106 interactions

InteractorPartnerSourcesPublicationsLink
NOS3NOSTRINBioGRID, HPRD, MINT, UniProt12446846 16234328 details
NOS3CALM1BioGRID, IntAct11397791 19358819 20705923 22486744 9115269 details
NOS3CDC37BioGRID, IntAct21163940 details
NOS3GCDHBioGRID, IntAct21163940 details
NOS3ST13BioGRID, IntAct21163940 details
NOS3FIS1BioGRID, IntAct21163940 details
NOS3EFEMP1BioGRID, IntAct21163940 details
NOS3EFEMP2BioGRID, IntAct21163940 details
NOS3ACTN2BioGRID, IntAct21163940 details
NOS3TXNDC11BioGRID, IntAct21163940 details
NOS3HTRA1BioGRID, IntAct21163940 details
NOS3MPRIPBioGRID, IntAct21163940 details
NOS3IMMTBioGRID, IntAct21163940 details
NOS3RNF31BioGRID, IntAct21163940 details
NOS3UMPSBioGRID, IntAct21163940 details
NOS3ACTN4BioGRID, IntAct21163940 details
NOS3H3-3ABioGRID, IntAct21163940 details
NOS3H3-3BIntAct21163940 details
NOS3A2MBioGRID, IntAct21163940 details
NOS3EXOC6BioGRID, IntAct21163940 details
NOS3MAST1BioGRID, IntAct21163940 details
NOS3ELAVL3BioGRID, IntAct21163940 details
NOS3RNF32BioGRID, IntAct21163940 details
NOS3KANK2BioGRID, IntAct21163940 details
NOS3ELAVL1BioGRID, IntAct21163940 details
NOS3PI4K2ABioGRID, IntAct21163940 details
NOS3AKT1BioGRID, HPRD, IntAct10376603 11425855 11696579 23397142 25241761 details
NOS3MAGEA11BioGRID, IntAct25416956 details
NOS3GOLGA2BioGRID, IntAct25416956 32296183 details
NOS3IKZF3BioGRID, IntAct32296183 details
NOS3ACTBBioGRID, DIP17502619 details
NOS3HBA1DIP23123858 details
NOS3HBA2DIP23123858 details
NOS3ZNF232IntAct32814053 details
NOS3PDZK1IntAct32814053 details
NOS3NVLIntAct32814053 details
NOS3KRT33BIntAct32814053 details
NOS3HNRNPKIntAct32814053 details
NOS3FANCGIntAct32814053 details
NOS3AP2B1IntAct32814053 details
NOS3NSMFIntAct32814053 details
NOS3SULT4A1IntAct32814053 details
NOS3MICAL2IntAct32814053 details
NOS3PCSK7IntAct32814053 details
NOS3HYAL2IntAct32814053 details
NOS3COPS3IntAct32814053 details
NOS3TRIM69IntAct32814053 details
NOS3RNF183IntAct32814053 details
NOS3C6orf141IntAct32814053 details
NOS3PPP1R21IntAct32814053 details
NOS3H3C14IntAct32814053 details
NOS3H3C15IntAct32814053 details
NOS3H3C13IntAct32814053 details
NOS3SPATA2LIntAct32814053 details
NOS3PPP1R16AIntAct32814053 details
NOS3MPNDIntAct32814053 details
NOS3WDR61IntAct32814053 details
NOS3REXO4IntAct32814053 details
NOS3ARFGAP1IntAct32814053 details
NOS3ASIC4IntAct32814053 details
NOS3PCMTD2IntAct32814053 details
NOS3THAP1IntAct32814053 details
NOS3RBM11IntAct32814053 details
NOS3WWOXIntAct32814053 details
NOS3CRLF3IntAct32814053 details
NOS3GPR75-ASB3IntAct32814053 details
NOS3ASB3IntAct32814053 details
NOS3UBQLN3IntAct32814053 details
NOS3KLHL20IntAct32814053 details
NOS3PIAS1IntAct32814053 details
NOS3LGALS9CIntAct32814053 details
NOS3VSX2IntAct32814053 details
NOS3SPRED2IntAct32814053 details
NOS3SPRED1IntAct32814053 details
NOS3METTL27IntAct32814053 details
NOS3SAMD3IntAct32814053 details
NOS3HSP90AA1BioGRID, HPRD11425855 11744239 11988487 12124224 12676772 details
NOS3GUCY1B1BioGRID12676772 details
NOS3NOSIPBioGRID, HPRD11149895 16135813 details
NOS3NOS3BioGRID, HPRD10074942 11149895 12176133 12437348 15721862 18849972 8995432 9115269 9516116 details
NOS3APPBioGRID21163940 details
NOS3APOEBioGRID21163940 details
NOS3CEP55BioGRID21163940 details
NOS3EXOSC1BioGRID21163940 details
NOS3PAXIP1BioGRID21163940 details
NOS3PSEN2BioGRID21163940 details
NOS3PSEN1BioGRID21163940 details
NOS3TECRBioGRID21163940 details
NOS3CALM2IntAct11397791 details
NOS3CALM3IntAct11397791 details
NOS3CTNNB1IntAct25062958 details
NOS3DNM1DIP16432212 details
NOS3CAV1BioGRID, DIP, HPRD11425855 12852865 17502619 8910295 details
NOS3SIRT1BioGRID, DIP20479254 details
NOS3HDAC3BioGRID20705923 details
NOS3CAMK2ABioGRID11397791 details
NOS3PTPABioGRID28760745 details
NOS3KEAP1BioGRID31491600 details
NOS3BDKRB2HPRD10510297 10681501 details
NOS3BDNFHPRD10493752 details
NOS3NMT1HPRD7512951 details
NOS3SP1HPRD7541039 details
NOS3PPP2R5AHPRD11397791 12501214 details
NOS3EDNRBHPRD10510297 details
NOS3AGTR1HPRD10510297 details
NOS3ESR1DIP17921256 details