Entity Details

Primary name IBP7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16270
EntryNameIBP7_HUMAN
FullNameInsulin-like growth factor-binding protein 7
TaxID9606
Evidenceevidence at protein level
Length282
SequenceStatuscomplete
DateCreated2002-09-19
DateModified2021-06-02

Ontological Relatives

GenesIGFBP7

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0005520 insulin-like growth factor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007155 cell adhesion
GO:0007566 embryo implantation
GO:0008285 negative regulation of cell population proliferation
GO:0009408 response to heat
GO:0009966 regulation of signal transduction
GO:0032526 response to retinoic acid
GO:0032870 cellular response to hormone stimulus
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050810 regulation of steroid biosynthetic process
GO:0051414 response to cortisol
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR002350 Kazal domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25FamilyFamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614224 OMIMRetinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS)An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00071 Insulin porkDrugbankbiotech